PMID- 29907807
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20200224
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 54
IP  - 2
DP  - 2019 Feb
TI  - Availability of HLA-allele-matched unrelated donors: estimation from haplotype 
      frequency in the Japanese population.
PG  - 300-303
LID - 10.1038/s41409-018-0263-9 [doi]
AB  - A human leukocyte antigen (HLA)-matched unrelated donor is the primary 
      alternative donor for allogeneic hematopoietic cell transplantation in Japan. In 
      considering an optimal donor registry size, the availability of HLA-matched 
      donors is important. In this study, the probability of finding an HLA-A, -B, -C, 
      and -DRB1 allele-matched donor was estimated using two different methods based on 
      the haplotype frequencies in the Japanese population: an actual measurement 
      method (AMM) and a formula method (FM). According to AMM, the probabilities of 
      finding an HLA-matched donor were 40.5% in 100,000 donors, 54.4% in 300,000, 
      60.0% in 500,000, and 63.4% in 700,000. On the other hand, according to FM, the 
      probabilities were 47.8% in 100,000 donors, 59.9% in 300,000, 65.3% in 500,000, 
      and 68.8% in 700,000. The probabilities increased by 8.6 or 7.7%, 3.2 or 3.1%, 
      2.1 or 1.9%, and 1.6 or 1.3% in AMM or FM, respectively, as the registry size 
      increased by 100,000. The rate of increase in the probability of finding an 
      HLA-matched donor will become smaller as the registry size increases due to the 
      diversity of haplotypes. Therefore, it is important to set a target donor 
      registry size for efficient donor recruitment by considering the haplotype 
      frequencies in the population.
FAU - Nishiwaki, Satoshi
AU  - Nishiwaki S
AUID- ORCID: 0000-0002-6430-8958
AD  - Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, 
      Nagoya, Japan. n-3104@tf7.so-net.ne.jp.
FAU - Tanaka, Hidenori
AU  - Tanaka H
AD  - HLA Foundation Laboratory, Kyoto, Japan.
FAU - Kojima, Hiroto
AU  - Kojima H
AD  - HLA Foundation Laboratory, Kyoto, Japan.
FAU - Okamoto, Shinichiro
AU  - Okamoto S
AD  - Division of Hematology, Department of Internal Medicine, Keio University School 
      of Medicine, Tokyo, Japan.
LA  - eng
GR  - JP17K16186/Japan Society for the Promotion of Science (JSPS)/International
GR  - 18ek0510014h0003/Japan Agency for Medical Research and Development 
      (AMED)/International
GR  - 18ek0510014h0003/Japan Agency for Medical Research and Development 
      (AMED)/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180615
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Genotype
MH  - HLA Antigens/*immunology
MH  - Haplotypes/genetics/immunology
MH  - Histocompatibility/*immunology
MH  - Humans
MH  - Japan/epidemiology
MH  - Models, Genetic
MH  - Probability
MH  - Registries
MH  - Sample Size
MH  - Unrelated Donors/*supply & distribution
EDAT- 2018/06/17 06:00
MHDA- 2020/02/25 06:00
CRDT- 2018/06/17 06:00
PHST- 2018/02/15 00:00 [received]
PHST- 2018/06/04 00:00 [accepted]
PHST- 2018/05/30 00:00 [revised]
PHST- 2018/06/17 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2018/06/17 06:00 [entrez]
AID - 10.1038/s41409-018-0263-9 [pii]
AID - 10.1038/s41409-018-0263-9 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2019 Feb;54(2):300-303. doi: 10.1038/s41409-018-0263-9. 
      Epub 2018 Jun 15.