PMID- 29908832
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 270
DP  - 2018 Nov 1
TI  - Cardiac resynchronization therapy guided by cardiac magnetic resonance imaging: A 
      prospective, single-centre randomized study (CMR-CRT).
PG  - 325-330
LID - S0167-5273(18)30115-3 [pii]
LID - 10.1016/j.ijcard.2018.06.009 [doi]
AB  - BACKGROUND: Cardiac resynchronization therapy (CRT) improves symptoms of heart 
      failure (HF), morbidity and mortality in selected population. The aim of the 
      study was to investigate the impact of cardiac magnetic resonance (CMR)-guided 
      left ventricular (LV) lead placement on clinical outcomes and LV reverse 
      remodelling in CRT recipients. METHODS: Patients with CRT indication were 
      randomized for CMR-guided (CMR group) or electrophysiologically guided (EP group) 
      LV lead placement between 2011 and 2014. The target site in the CMR group was 
      defined as the most delayed, scar-free, in the EP group as the site with the 
      longest interval between the QRS onset and local electrogram. The primary 
      endpoint was a combination of cardiovascular death or HF hospitalization. 
      Secondary endpoints were New York Heart Association (NYHA) Class improvement >/=1, 
      LV endsystolic diameter reduction >10%, B-type natriuretic peptide reduction by 
      >/=30%. RESULTS: A total of 99 patients (47 in the CMR and 52 in the EP group) were 
      enrolled. During a median follow-up of 47 months, primary composite endpoint 
      occurred in 5 patients in the CMR group and 14 patients in the EP group 
      (HR = 0.46; 95% CI: 0.16-1.32). Patients with left bundle branch block and NYHA 
      Class >2 had better clinical outcome in the CMR group (HR = 0.09; 95% CI: 
      0.01-0.75). CONCLUSIONS: The use of CMR did not result in significant reduction 
      of combined endpoint of cardiovascular death or HF hospitalization in the total 
      study population. Significant clinical benefit from CMR-guided procedure was 
      observed in a subgroup of optimum CRT candidates with advanced HF.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Kockova, Radka
AU  - Kockova R
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic; Charles University, Faculty of 
      Medicine in Hradec Kralove, Simkova 870, Hradec Kralove 500 03, Czech Republic. 
      Electronic address: radka.kockova@ikem.cz.
FAU - Sedlacek, Kamil
AU  - Sedlacek K
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Wichterle, Dan
AU  - Wichterle D
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic; Charles University, First 
      Faculty of Medicine, Katerinska 32, Praha 121 08, Czech Republic.
FAU - Sikula, Viktor
AU  - Sikula V
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Tintera, Jaroslav
AU  - Tintera J
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Jansova, Helena
AU  - Jansova H
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Praveckova, Alena
AU  - Praveckova A
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Langova, Renata
AU  - Langova R
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Kryze, Lukas
AU  - Kryze L
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - El-Husseini, Wael
AU  - El-Husseini W
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Segetova, Marketa
AU  - Segetova M
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
FAU - Kautzner, Josef
AU  - Kautzner J
AD  - Institute for Clinical and Experimental Medicine, Department of Cardiology, 
      Videnska 1958/9, Prague 4 140 21, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180606
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2018 Nov 1;270:353-354. PMID: 30049489
MH  - Aged
MH  - Cardiac Resynchronization Therapy/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*diagnostic imaging/physiopathology/*therapy
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Heart failure
OT  - Magnetic resonance
OT  - Resynchronization therapy
OT  - Target segment
EDAT- 2018/06/18 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/06/18 06:00
PHST- 2018/01/07 00:00 [received]
PHST- 2018/05/22 00:00 [revised]
PHST- 2018/06/04 00:00 [accepted]
PHST- 2018/06/18 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/06/18 06:00 [entrez]
AID - S0167-5273(18)30115-3 [pii]
AID - 10.1016/j.ijcard.2018.06.009 [doi]
PST - ppublish
SO  - Int J Cardiol. 2018 Nov 1;270:325-330. doi: 10.1016/j.ijcard.2018.06.009. Epub 
      2018 Jun 6.