PMID- 29909622
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20190313
LR  - 20190313
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 90
IP  - 14
DP  - 2018 Jul 17
TI  - Efficient Extraction of Sulfur and Nitrogen Mustards from Nonpolar Matrix and an 
      Investigation on Their Sorption Behavior on Silica.
PG  - 8295-8299
LID - 10.1021/acs.analchem.8b02157 [doi]
AB  - Extraction of vesicant class of chemical warfare agents (CWAs) such as sulfur 
      mustard and nitrogen mustards from the environmental matrices is of prime 
      importance, from a forensic and verification viewpoint of the Chemical Weapons 
      Convention (CWC). For extraction of Convention Related Compounds from nonpolar 
      organic medium, commercially available silica cartridges are used extensively, 
      but silica cartridges exhibit limited efficiency toward vesicant classes of 
      compounds. It is expected that sulfur mustard being nonpolar does not retain 
      sufficiently on silica surface, and nitrogen mustards (being basic) are strongly 
      adsorbed on acidic silica surface, resulting in their poor recoveries. Contrary 
      to the expected higher recovery of sulfur mustard over nitrogen mustards, it was 
      observed that the recovery of sulfur mustard was lower than that of nitrogen 
      mustards with the silica based sorbent. The reason for this typical behavior of 
      these agents on silica was investigated. This study was aimed to develop an 
      analytical method for efficient extraction and enrichment of sulfur and nitrogen 
      mustards from hydrophobic matrices. In this work, the polymeric sorbent was 
      synthesized with polar methacrylic acid (MAA) as monomer and ethylene glycol 
      dimethacrylate (EGDMA) as cross-linker and used for solid phase extraction (SPE) 
      of sulfur mustard and nitrogen mustards. The extraction efficiency of the 
      polymeric sorbent was optimized and compared with that of silica cartridges. Both 
      classes of analytes were recovered in good amounts from the polymeric sorbent 
      compared to silica. The extraction parameters were optimized for the proposed 
      method which included extraction solvent ethyl acetate and washing solvent 
      n-hexane (1 mL). The recoveries of the analytes ranged from 75 to 87% with 
      relative standard deviations (RSDs) lower than 9%. The limit of detection (LOD) 
      was found to be in the range of 0.075-0.150 mug mL(-1), and limit of 
      quantification (LOQ) was >0.25 mug mL(-1). The linear dynamic range of optimized 
      method was found to be 0.50-20 mug mL(-1) ( r(2) = 0.9994) for sulfur mustard and 
      0.25-20 mug mL(-1) ( r(2) = 0.9897-0.9987) for nitrogen mustards, respectively.
FAU - Sinha Roy, Kanchan
AU  - Sinha Roy K
AUID- ORCID: 0000-0001-7726-6788
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior 474002 , Madhya Pradesh , India.
FAU - Goud, D Raghavender
AU  - Goud DR
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior 474002 , Madhya Pradesh , India.
FAU - Chandra, Buddhadeb
AU  - Chandra B
AUID- ORCID: 0000-0003-0146-8804
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior 474002 , Madhya Pradesh , India.
FAU - Dubey, Devendra Kumar
AU  - Dubey DK
AUID- ORCID: 0000-0003-3820-2233
AD  - VERTOX Laboratory , Defence Research and Development Establishment , Jhansi Road 
      , Gwalior 474002 , Madhya Pradesh , India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180627
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
EDAT- 2018/06/19 06:00
MHDA- 2018/06/19 06:01
CRDT- 2018/06/19 06:00
PHST- 2018/06/19 06:00 [pubmed]
PHST- 2018/06/19 06:01 [medline]
PHST- 2018/06/19 06:00 [entrez]
AID - 10.1021/acs.analchem.8b02157 [doi]
PST - ppublish
SO  - Anal Chem. 2018 Jul 17;90(14):8295-8299. doi: 10.1021/acs.analchem.8b02157. Epub 
      2018 Jun 27.