PMID- 29911057
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 2231-0762 (Print)
IS  - 2250-1002 (Electronic)
IS  - 2231-0762 (Linking)
VI  - 8
IP  - 3
DP  - 2018 May-Jun
TI  - Antifungal Efficacy and the Mechanical Properties of Soft Liners against Candida 
      albicans after the Incorporation of Garlic and Neem: An In vitro Study.
PG  - 212-217
LID - 10.4103/jispcd.JISPCD_343_17 [doi]
AB  - OBJECTIVES: To evaluate the in vitro growth inhibition of Candida albicans, in 
      the soft-liner material and Shore A hardness from resin-based denture soft lining 
      materials modified by neem or garlic incorporation. MATERIALS AND METHODS: Resin 
      discs were prepared with poly methyl methacrylate (PMMA) and soft liners 
      incorporated with varying concentrations of neem or garlic. For antifungal 
      activity, resin discs were placed on agar plates inoculated with C. albicans and 
      were evaluated after 2, 4, and 7 days using the streaking method. The hardness of 
      the PMMA was evaluated with the use of Shore A at 2, 4, and 7 days. Data were 
      statistically processed by SPSS software (IBM Company, Chicago, USA) using 
      Kruskal-Wallis test, and post hoc comparisons were done using Dunn's test. P 
      <0.05 was considered statistically significant. RESULTS: Neem and garlic added to 
      PMMA soft liner had an inhibitory effect on C. albicans. Both the neem and garlic 
      when added showed positive results against C. albicans when compared to the 
      control group. The soft liner hardness increased statistically by time but not 
      for the different plant extract concentrations. CONCLUSIONS: Within the 
      limitations of this in vitro study, it was found that neem and garlic can be used 
      as an additive to tissue conditioner to reduce the adherence of C. albicans 
      without significantly affecting the hardness of the heat-polymerized acrylic 
      resin.
FAU - Kumar, Seenivasan Madhan
AU  - Kumar SM
AD  - Department of Prosthodontics, Sri Ramachandra University, Chennai, Tamil Nadu, 
      India.
FAU - Kumar, V Anand
AU  - Kumar VA
AD  - Department of Prosthodontics, Sri Ramachandra University, Chennai, Tamil Nadu, 
      India.
FAU - Natarajan, Parathasarthy
AU  - Natarajan P
AD  - Department of Prosthodontics, Sri Ramachandra University, Chennai, Tamil Nadu, 
      India.
FAU - Sreenivasan, Gayathri
AU  - Sreenivasan G
AD  - Department of Prosthodontics, Sri Ramachandra University, Chennai, Tamil Nadu, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20180517
PL  - India
TA  - J Int Soc Prev Community Dent
JT  - Journal of International Society of Preventive & Community Dentistry
JID - 101618802
PMC - PMC5985676
OTO - NOTNLM
OT  - Antifungal property and tissue conditioners
OT  - Candida albicans
OT  - garlic
OT  - neem
COIS- There are no conflicts of interest.
EDAT- 2018/06/19 06:00
MHDA- 2018/06/19 06:01
PMCR- 2018/05/01
CRDT- 2018/06/19 06:00
PHST- 2017/09/28 00:00 [received]
PHST- 2018/04/02 00:00 [accepted]
PHST- 2018/06/19 06:00 [entrez]
PHST- 2018/06/19 06:00 [pubmed]
PHST- 2018/06/19 06:01 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - JISPCD-8-212 [pii]
AID - 10.4103/jispcd.JISPCD_343_17 [doi]
PST - ppublish
SO  - J Int Soc Prev Community Dent. 2018 May-Jun;8(3):212-217. doi: 
      10.4103/jispcd.JISPCD_343_17. Epub 2018 May 17.