PMID- 29912347
OWN - NLM
STAT- MEDLINE
DCOM- 20190508
LR  - 20190802
IS  - 1464-3685 (Electronic)
IS  - 0300-5771 (Print)
IS  - 0300-5771 (Linking)
VI  - 47
IP  - 4
DP  - 2018 Aug 1
TI  - Prenatal and postnatal exposure to persistent organic pollutants and 
      attention-deficit and hyperactivity disorder: a pooled analysis of seven European 
      birth cohort studies.
PG  - 1082-1097
LID - 10.1093/ije/dyy052 [doi]
AB  - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is increasing 
      worldwide for reasons largely unknown and environmental chemicals with neurotoxic 
      properties, such as persistent organic pollutants (POPs), have been proposed to 
      play a role. We investigated the association between prenatal and postnatal 
      exposure to polychlorinated biphenyl-153 (PCB-153), 
      p-p -dichlorodiphenyldichloroethylene (p-p'-DDE) and hexachlorobenzene (HCB) and 
      ADHD in childhood. METHODS: We pooled seven European birth cohort studies 
      encompassing 4437 mother-child pairs from the general population with 
      concentrations of PCB-153, p-p -DDE and HCB measured in cord blood, maternal 
      blood or milk. We then calculated prenatal (birth) and postnatal (3, 6, 12 and 
      24 months) POP concentrations using a pharmacokinetic model. The operational 
      definition of ADHD varied across cohorts and ranged from doctor diagnosis 
      obtained from patient registries to maternal or teachers reports. We used 
      multilevel (mixed) logistic regression models to estimate the associations 
      between exposure to POPs at birth, 3, 6, 12 and 24 months and ADHD. RESULTS: The 
      global prevalence of ADHD in our study was 6%. The mean age at assessment of ADHD 
      was 5.8 years (range: 3.8-9.5 years). We found no association between exposure to 
      PCB-153, p-p -DDE and HCB at any age point between birth and 24 months and ADHD, 
      in the pooled analyses (pooled odds ratios ranging from 1.00 to 1.01). A number 
      of sensitivity analyses gave basically the same results. CONCLUSIONS: In the 
      largest study to date of 4437 children in seven European birth cohorts, we did 
      not observe any association between either pre- or postnatal exposure (up to 
      24 months) to PCB-153, p-p -DDE and HCB and the risk of ADHD before the age of 
      10 years.
FAU - Forns, Joan
AU  - Forns J
AD  - Department of Environmental Exposure and Epidemiology, Norwegian Institute of 
      Public Health, Oslo, Norway.
FAU - Stigum, Hein
AU  - Stigum H
AD  - Department of Non-Communicable Diseases, Norwegian Institute of Public Health, 
      Oslo, Norway.
FAU - Hoyer, Birgit Bjerre
AU  - Hoyer BB
AD  - Department of Occupational and Environmental Medicine, Bispebjerg University 
      Hospital, Copenhagen, Denmark.
AD  - Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Sioen, Isabelle
AU  - Sioen I
AD  - Department of Food Technology, Safety and Health, Ghent University, Ghent, 
      Belgium.
FAU - Sovcikova, Eva
AU  - Sovcikova E
AD  - Department of Environmental Medicine, Faculty of Public Health, Slovak Medical 
      University, Bratislava, Slovak Republic.
FAU - Nowack, Nikola
AU  - Nowack N
AD  - Department of Developmental Psychology, Ruhr University Bochum, Bochum, Germany.
FAU - Lopez-Espinosa, Maria-Jose
AU  - Lopez-Espinosa MJ
AD  - Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat 
      Jaume I-Universitat de Valencia, Valencia, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Barcelona, Spain.
FAU - Guxens, Monica
AU  - Guxens M
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Barcelona, Spain.
AD  - ISGlobal, Center for Research in Environmental Epidemiology, Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Department of Child and Adolescent Psychiatry/Psychology, Erasmus University 
      Medical Centre-Sophia Children's Hospital, Rotterdam, the Netherlands.
FAU - Ibarluzea, Jesus
AU  - Ibarluzea J
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Barcelona, Spain.
AD  - Sub-Directorate for Public Health of Gipuzkoa, Department of Health of the Basque 
      Country, San Sebastian, Spain.
AD  - BIODONOSTIA Health Research Institute, Basque Country, Spain.
AD  - Faculty of Psychology, University of the Basque Country, San Sebastian, Spain.
FAU - Torrent, Matias
AU  - Torrent M
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Menorca Health Area, Balearic Health Service (ib-salut), Menorca, Spain.
FAU - Wittsiepe, Jurgen
AU  - Wittsiepe J
AD  - Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 
      Bochum, Germany.
FAU - Govarts, Eva
AU  - Govarts E
AD  - Unit Environmental Risk and Health, Flemish Institute for Technological Research 
      (VITO), Mol, Belgium.
FAU - Trnovec, Tomas
AU  - Trnovec T
AD  - Faculty of Public Health, Department of Environmental Medicine, Slovak Medical 
      University, Bratislava, Slovakia.
FAU - Chevrier, Cecile
AU  - Chevrier C
AD  - INSERM, UMR1085 IRSET, University Rennes 1, Rennes, France.
FAU - Toft, Gunnar
AU  - Toft G
AD  - Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Vrijheid, Martine
AU  - Vrijheid M
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Instituto de Salud Carlos III, Barcelona, Spain.
AD  - ISGlobal, Center for Research in Environmental Epidemiology, Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
FAU - Iszatt, Nina
AU  - Iszatt N
AD  - Department of Environmental Exposure and Epidemiology, Norwegian Institute of 
      Public Health, Oslo, Norway.
FAU - Eggesbo, Merete
AU  - Eggesbo M
AD  - Department of Environmental Exposure and Epidemiology, Norwegian Institute of 
      Public Health, Oslo, Norway.
LA  - eng
GR  - R01 CA096525/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Epidemiol
JT  - International journal of epidemiology
JID - 7802871
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Adolescent
MH  - Attention Deficit Disorder with Hyperactivity/*epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*analysis
MH  - Europe/epidemiology
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Hexachlorobenzene/blood
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - *Maternal Exposure
MH  - Polychlorinated Biphenyls/blood
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/epidemiology
PMC - PMC6124627
EDAT- 2018/06/19 06:00
MHDA- 2019/05/09 06:00
PMCR- 2019/08/01
CRDT- 2018/06/19 06:00
PHST- 2018/03/14 00:00 [received]
PHST- 2018/03/27 00:00 [accepted]
PHST- 2018/06/19 06:00 [pubmed]
PHST- 2019/05/09 06:00 [medline]
PHST- 2018/06/19 06:00 [entrez]
PHST- 2019/08/01 00:00 [pmc-release]
AID - 4975495 [pii]
AID - dyy052 [pii]
AID - 10.1093/ije/dyy052 [doi]
PST - ppublish
SO  - Int J Epidemiol. 2018 Aug 1;47(4):1082-1097. doi: 10.1093/ije/dyy052.