PMID- 29912955
OWN - NLM
STAT- MEDLINE
DCOM- 20190411
LR  - 20190411
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 6
DP  - 2018
TI  - Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled 
      analysis of controlled studies in healthy subjects.
PG  - e0199384
LID - 10.1371/journal.pone.0199384 [doi]
LID - e0199384
AB  - Methylenedioxymethamphetamine (MDMA) increases oxytocin, empathy, and 
      prosociality. Oxytocin plays a critical role in emotion processing and social 
      behavior and has been shown to mediate the prosocial effects of MDMA in animals. 
      Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the oxytocin 
      receptor (OXTR) may influence the emotional and social effects of MDMA in humans. 
      The effects of common genetic variants of the OXTR (rs53576, rs1042778, and 
      rs2254298 SNPs) on the emotional, empathogenic, and prosocial effects of MDMA 
      were characterized in up to 132 healthy subjects in a pooled analysis of eight 
      double-blind, placebo-controlled studies. In a subset of 53 subjects, MDMA 
      produced significantly greater feelings of trust in rs1042778 TT genotypes 
      compared with G allele carriers. The rs53576 and rs225498 SNPs did not moderate 
      the subjective effects of MDMA in up to 132 subjects. None of the SNPs moderated 
      MDMA-induced impairments in negative facial emotion recognition or enhancements 
      in emotional empathy in the Multifaceted Empathy Test in 69 subjects. MDMA 
      significantly increased plasma oxytocin concentrations. MDMA and oxytocin 
      concentrations did not differ between OXTR gene variants. The present results 
      provide preliminary evidence that OXTR gene variations may modulate aspects of 
      the prosocial subjective effects of MDMA in humans. However, interpretation 
      should be cautious due to the small sample size. Additionally, OXTR SNPs did not 
      moderate the subjective overall effect of MDMA (any drug effect) or feelings of 
      "closeness to others". TRIAL REGISTRATION: ClinicalTrials.gov: 
      http://www.clinicaltrials.gov, No: NCT00886886, NCT00990067, NCT01136278, 
      NCT01270672, NCT01386177, NCT01465685, NCT01771874, and NCT01951508.
FAU - Vizeli, Patrick
AU  - Vizeli P
AD  - Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and 
      Department of Clinical Research, University Hospital Basel and University of 
      Basel, Basel, Switzerland.
FAU - Liechti, Matthias E
AU  - Liechti ME
AUID- ORCID: 0000-0002-1765-9659
AD  - Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and 
      Department of Clinical Research, University Hospital Basel and University of 
      Basel, Basel, Switzerland.
LA  - eng
SI  - ClinicalTrials.gov/NCT00886886
SI  - ClinicalTrials.gov/NCT01386177
SI  - ClinicalTrials.gov/NCT01951508
SI  - ClinicalTrials.gov/NCT00990067
SI  - ClinicalTrials.gov/NCT01270672
SI  - ClinicalTrials.gov/NCT01465685
SI  - ClinicalTrials.gov/NCT01771874
SI  - ClinicalTrials.gov/NCT01136278
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180618
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (OXTR protein, human)
RN  - 0 (Receptors, Oxytocin)
RN  - 50-56-6 (Oxytocin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Empathy/drug effects/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/adverse effects
MH  - Oxytocin/antagonists & inhibitors/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Receptors, Oxytocin/*genetics
MH  - Social Behavior
MH  - Social Behavior Disorders/*drug therapy/genetics/pathology
MH  - Young Adult
PMC - PMC6005537
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/06/19 06:00
MHDA- 2019/04/12 06:00
PMCR- 2018/06/18
CRDT- 2018/06/19 06:00
PHST- 2017/11/23 00:00 [received]
PHST- 2018/03/26 00:00 [accepted]
PHST- 2018/06/19 06:00 [entrez]
PHST- 2018/06/19 06:00 [pubmed]
PHST- 2019/04/12 06:00 [medline]
PHST- 2018/06/18 00:00 [pmc-release]
AID - PONE-D-17-38437 [pii]
AID - 10.1371/journal.pone.0199384 [doi]
PST - epublish
SO  - PLoS One. 2018 Jun 18;13(6):e0199384. doi: 10.1371/journal.pone.0199384. 
      eCollection 2018.