PMID- 29915815
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2468-4511 (Print)
IS  - 2468-4511 (Electronic)
IS  - 2468-4511 (Linking)
VI  - 5
DP  - 2018 Mar
TI  - Modeling the blood-brain barrier: Beyond the endothelial cells.
PG  - 6-12
LID - 10.1016/j.cobme.2017.11.002 [doi]
AB  - The blood-brain barrier (BBB) regulates the transport of ions, nutrients, and 
      metabolites to help maintain proper brain function. This restrictive interface 
      formed by brain microvascular endothelial cells excludes the majority of small 
      and large molecule drugs from entering the brain, and blood-brain barrier 
      dysfunction is a signature of many neurological diseases. Thus, in vitro models 
      of the BBB based on brain endothelial cells have been developed to facilitate 
      screening drugs for BBB permeability. However, while brain endothelial cells form 
      the main interface, they work in concert with other brain-resident cells such as 
      neural progenitor cells, pericytes, astrocytes, and neurons to form the 
      neurovascular unit (NVU). Importantly, non-endothelial cells of the NVU play key 
      roles in eliciting BBB phenotypes and in regulating the dynamic responses of the 
      BBB to brain activity and disease. As a result, emerging in vitro BBB models have 
      incorporated these NVU cell types in addition to endothelial cells. These 
      multicellular BBB or NVU models have found increasing application not only in 
      drug screening, but also in studying complex cellular and molecular mechanisms 
      underlying BBB biology and disease.
FAU - Gastfriend, Benjamin D
AU  - Gastfriend BD
AD  - Department of Chemical and Biological Engineering, University of 
      Wisconsin-Madison, 1415 Engineering Drive, Madison WI, 53706.
FAU - Palecek, Sean P
AU  - Palecek SP
AD  - Department of Chemical and Biological Engineering, University of 
      Wisconsin-Madison, 1415 Engineering Drive, Madison WI, 53706.
FAU - Shusta, Eric V
AU  - Shusta EV
AD  - Department of Chemical and Biological Engineering, University of 
      Wisconsin-Madison, 1415 Engineering Drive, Madison WI, 53706.
LA  - eng
GR  - R01 NS083688/NS/NINDS NIH HHS/United States
GR  - T32 GM008349/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Curr Opin Biomed Eng
JT  - Current opinion in biomedical engineering
JID - 101704011
PMC - PMC6003712
MID - NIHMS926113
OTO - NOTNLM
OT  - Astrocytes
OT  - Blood-Brain Barrier
OT  - Brain Endothelial Cells
OT  - Neurons
OT  - Neurovascular Unit
OT  - Pericytes
EDAT- 2018/06/20 06:00
MHDA- 2018/06/20 06:01
PMCR- 2019/03/01
CRDT- 2018/06/20 06:00
PHST- 2018/06/20 06:00 [entrez]
PHST- 2018/06/20 06:00 [pubmed]
PHST- 2018/06/20 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 10.1016/j.cobme.2017.11.002 [doi]
PST - ppublish
SO  - Curr Opin Biomed Eng. 2018 Mar;5:6-12. doi: 10.1016/j.cobme.2017.11.002.