PMID- 29915860
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20181114
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 39
IP  - 6
DP  - 2018 Jun
TI  - Pediatric systemic lupus erythematosus. Retrospective analysis of 
      clinico-laboratory parameters and their association with Systemic Lupus 
      Erythematosus Disease Activity Index score.
PG  - 627-631
LID - 10.15537/smj.2018.6.22112 [doi]
AB  - OBJECTIVES: To elucidate the clinico-laboratory characteristics associated with 
      pediatric systemic lupus erythematosus (pSLE) patients with higher Systemic Lupus 
      Erythematosus Disease Activity Index (SLEDAI) score in a retrospective cohort of 
      pSLE patients. METHODS: A retrospective study involving 32 pSLE patients was 
      conducted at Hospital Universiti Sains Malaysia, Kelantan, Malaysia between 2006 
      and 2017. RESULTS: Within the group of 32 pSLE patients, 23 were girls and 9 were 
      boys (3:1 ratio). The most common symptom was renal disorder (n=21; 65.6%) 
      followed by malar rash (n=9; 28.1%), oral ulcers (n=7; 21.9%), prolonged fever 
      (n=5; 15.6%) and arthritis (n=4; 12.5%). Antinuclear antibodies (ANA) were 
      detected in all patients and 25 patients (78.1%) were positive for anti-double 
      stranded DNA (anti-dsDNA) antibodies. Eighteen (56.3%) patients had active SLE 
      (SLEDAI >/=6), and these patients were significantly associated with heavy pyuria 
      (p=0.004), a high ANA concentration (1:160; p=0.040, 1:320; p=0.006), elevated 
      ESR (p=0.006), low C3 levels (p=0.008), oral ulcers (p=0.010), heavy hematuria 
      (p=0.017) and heavy proteinuria (p=0.017), lupus erythematosus (LE)-nonspecific 
      lesion manifestations (p=0.019) and malar rash (p=0.044). CONCLUSION: Pediatric 
      systemic lupus erythematosus patients with higher SLEDAI score were most 
      significantly associated with pyuria, high ANA titers, and elevated ESR.
FAU - Nazri, Siti Khadijah S M
AU  - Nazri SKSM
AD  - Department of Immunology, School of Medical Sciences, Health Campus, Universiti 
      Sains Malaysia, Kelantan, Malaysia. E-mail. smnkhadijah1993@gmail.com.
FAU - Wong, Kah K
AU  - Wong KK
FAU - Hamid, Wan Zuraida W A
AU  - Hamid WZWA
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 0 (Antibodies, Antinuclear)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Saudi Med J. 2018 Aug;39(8):846-847. PMID: 30106426
CIN - Saudi Med J. 2018 Oct;39(10):1060. PMID: 30284593
MH  - Antibodies, Antinuclear/*blood
MH  - Child
MH  - Child, Preschool
MH  - DNA/immunology
MH  - Facial Dermatoses/etiology
MH  - Female
MH  - Hematuria/etiology
MH  - Humans
MH  - Infant
MH  - Kidney Diseases/etiology
MH  - Lupus Erythematosus, Systemic/*blood/complications
MH  - Male
MH  - Oral Ulcer/etiology
MH  - Proteinuria/etiology
MH  - Pyuria/etiology
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC6146216
EDAT- 2018/06/20 06:00
MHDA- 2018/11/09 06:00
PMCR- 2018/06/01
CRDT- 2018/06/20 06:00
PHST- 2018/06/20 06:00 [entrez]
PHST- 2018/06/20 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - SaudiMedJ-39-627 [pii]
AID - 10.15537/smj.2018.6.22112 [doi]
PST - ppublish
SO  - Saudi Med J. 2018 Jun;39(6):627-631. doi: 10.15537/smj.2018.6.22112.