PMID- 29917126
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Linking)
VI  - 21
IP  - 9
DP  - 2019 Aug 19
TI  - Genetic Susceptibility to Thirdhand-Smoke-Induced Lung Cancer Development.
PG  - 1294-1296
LID - 10.1093/ntr/nty127 [doi]
AB  - Recently, potential health concerns have been raised about thirdhand smoke (THS), 
      a much less well-understood type of smoke exposure defined as residual tobacco 
      smoke sorbed onto indoor surfaces after active smoking has ceased. THS exposure 
      is derived from the involuntary inhalation, ingestion, or dermal uptake of indoor 
      pollutants. The timescale for exposure to THS pollution is generally much longer 
      than secondhand smoke, and could stretch to days, months, or years (long-term, 
      low-level exposure). Recent studies showed that exposure to THS at early age in 
      mice can affect body weight, immunity, and lung cancer development. However, 
      adverse health effects of THS in human populations remain poorly understood and 
      many questions remain unanswered. One major question is how genetic factors 
      influence susceptibility to THS-induced health effects, especially tumor 
      development and whether there is an age-specific window of susceptibility for 
      these effects. By addressing these questions, we will provide a better 
      understanding of the effects of THS on human health and disease. This information 
      would address critical knowledge gaps that are required for the formulation of 
      policies related to indoor air quality. IMPLICATIONS: THS, the residual tobacco 
      smoke remaining in the environment after tobacco has been smoked, represents an 
      underestimated public health hazard. Evidence supports its widespread presence in 
      indoor environments. Vulnerable populations are believed to include infants and 
      children living in a smoking household exposed to THS and/or secondhand smoke, 
      and exposure has been identified as a risk factor for lung cancer later in life. 
      These and future studies will provide novel and important evidence of how 
      early-life exposure to THS affects cancer development and other diseases, which 
      should be useful for framing and enforcing new policies against passive smoking 
      in the world.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of the 
      Society for Research on Nicotine and Tobacco. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Hang, Bo
AU  - Hang B
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA.
FAU - Mao, Jian-Hua
AU  - Mao JH
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA.
AD  - Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, 
      Berkeley, CA.
FAU - Snijders, Antoine M
AU  - Snijders AM
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA.
AD  - Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, 
      Berkeley, CA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Air Pollution, Indoor/analysis
MH  - Animals
MH  - Family Characteristics
MH  - Genetic Predisposition to Disease/epidemiology/*genetics
MH  - Humans
MH  - Lung Neoplasms/*chemically induced/epidemiology/*genetics
MH  - Risk Factors
MH  - Smoking/*adverse effects/*genetics
MH  - Tobacco Smoke Pollution/*adverse effects
MH  - Vulnerable Populations
EDAT- 2018/06/20 06:00
MHDA- 2020/04/21 06:00
CRDT- 2018/06/20 06:00
PHST- 2018/04/09 00:00 [received]
PHST- 2018/06/15 00:00 [accepted]
PHST- 2018/06/20 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2018/06/20 06:00 [entrez]
AID - 5039570 [pii]
AID - 10.1093/ntr/nty127 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2019 Aug 19;21(9):1294-1296. doi: 10.1093/ntr/nty127.