PMID- 2991806
OWN - NLM
STAT- MEDLINE
DCOM- 19850919
LR  - 20190912
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 6
IP  - 3
DP  - 1985 Jun
TI  - The role of central dopaminergic systems in the behavioral effects of 
      H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH.
PG  - 183-90
AB  - In the present study the role of the central dopaminergic systems in the 
      behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was investigated. The 
      heptapeptide inhibited the extinction of active avoidance behavior if the 
      treatment was performed intracerebroventricularly (icv) in a dose of 1 microgram, 
      but was ineffective in a dose of 0.1 micrograms. If the peptide was injected into 
      the nucleus accumbens septi (NAS) in a dose of 1 microgram, 0.1 micrograms or 
      0.01 micrograms it inhibited the extinction, but in the latter dose its effect 
      was only a short one. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH in a dose of 1 microgram, 
      10 micrograms or 20 micrograms (icv) did not influence the turning activity of 
      unilateral substantia nigra (USN)-lesioned animals. These results suggest that 
      the NAS plays an important role in the behavioral action of 
      H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH and the heptapeptide has no direct dopamine 
      receptor stimulatory or dopamine-releasing effect in the striatum.
FAU - Vecsei, L
AU  - Vecsei L
FAU - Telegdy, G
AU  - Telegdy G
FAU - Bollok, I
AU  - Bollok I
FAU - Schally, A V
AU  - Schally AV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Oligopeptides)
RN  - 78107-95-6 (H-phenylalanyl-isoleucyl-tyrosyl-histidyl-seryl-tyrosyl-lysine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Behavior, Animal/*drug effects
MH  - Brain/*drug effects
MH  - Corpus Striatum/drug effects
MH  - Dopamine/*physiology
MH  - Extinction, Psychological/drug effects
MH  - Male
MH  - Motor Activity/drug effects
MH  - Nucleus Accumbens/drug effects
MH  - Oligopeptides/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rotation
MH  - Synaptic Transmission/*drug effects
EDAT- 1985/06/01 00:00
MHDA- 1985/06/01 00:01
CRDT- 1985/06/01 00:00
PHST- 1985/06/01 00:00 [pubmed]
PHST- 1985/06/01 00:01 [medline]
PHST- 1985/06/01 00:00 [entrez]
AID - 0143-4179(85)90089-7 [pii]
AID - 10.1016/0143-4179(85)90089-7 [doi]
PST - ppublish
SO  - Neuropeptides. 1985 Jun;6(3):183-90. doi: 10.1016/0143-4179(85)90089-7.