PMID- 2991972
OWN - NLM
STAT- MEDLINE
DCOM- 19850911
LR  - 20131121
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 103
IP  - 2
DP  - 1985 Aug
TI  - Late functional and biochemical changes in mouse lung after irradiation: 
      differential effects of WR-2721.
PG  - 219-31
AB  - The radioprotective effect of WR-2721 on late damage after whole thorax 
      irradiation has been studied after split doses of radiation using the standard 
      death and breathing rate assays at monthly intervals between 3 and 15 months 
      after irradiation, as well as two biochemical measurements of injury at 15 
      months, hydroxyproline (HP), an indicator of tissue fibrosis, and DNA content, an 
      indicator of tissue cellularity. A comparison of HP/lung and breaths per minute 
      (BPM) in each dose group in the WR-2721 and non-WR-2721-treated mice 15 months 
      after irradiation showed that the relationship between these two assays of late 
      lung injury was not the same. There were large dose-related increases in 
      breathing rate corresponding to relatively small changes in HP in the lungs of 
      mice given radiation alone. In contrast, the mice given WR-2721 before 
      irradiation showed large dose-related increases in HP/lung, but BPM remained 
      relatively constant independent of dose. These data suggest then that changes in 
      breathing rate and deaths later than 9 months after whole lung irradiation may 
      not be due to collagen accumulation in the lung. WR-2721 did protect better 
      against late lung functional changes (protection factors (PF) = 1.6) and late 
      deaths (PF = 1.51) than against earlier changes in these same assays (PF = 1.4 
      and 1.28, respectively). Although the earlier-appearing injury after whole 
      thoracic irradiation is most likely related to lung damage with deaths and 
      increases in breathing rate resulting from pneumonitis, the cause of the 
      late-appearing functional injury in the lung after radiation is not clear. Thus 
      protection of late lung damage measured from either lethality or breathing rate 
      is not related to the prevention of lung fibrosis.
FAU - Travis, E L
AU  - Travis EL
FAU - Meistrich, M L
AU  - Meistrich ML
FAU - Finch-Neimeyer, M V
AU  - Finch-Neimeyer MV
FAU - Watkins, T L
AU  - Watkins TL
FAU - Kiss, I
AU  - Kiss I
LA  - eng
GR  - CA-06294/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
RN  - 0 (Cesium Radioisotopes)
RN  - 0 (Organothiophosphorus Compounds)
RN  - 9007-49-2 (DNA)
RN  - M487QF2F4V (Amifostine)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Amifostine/*therapeutic use
MH  - Animals
MH  - Cesium Radioisotopes
MH  - DNA/analysis
MH  - Dose-Response Relationship, Radiation
MH  - Hydroxyproline/analysis
MH  - Lung/analysis/drug effects/*radiation effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Organothiophosphorus Compounds/*therapeutic use
MH  - Radiation Injuries, Experimental/mortality/*prevention & control
MH  - Time Factors
EDAT- 1985/08/01 00:00
MHDA- 1985/08/01 00:01
CRDT- 1985/08/01 00:00
PHST- 1985/08/01 00:00 [pubmed]
PHST- 1985/08/01 00:01 [medline]
PHST- 1985/08/01 00:00 [entrez]
PST - ppublish
SO  - Radiat Res. 1985 Aug;103(2):219-31.