PMID- 29920090
OWN - NLM
STAT- MEDLINE
DCOM- 20180814
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 66
IP  - 29
DP  - 2018 Jul 25
TI  - Trace Level Analysis of Sarin and VX in Food Using Normal Phase Silica Gel and 
      Ultra-Performance Liquid Chromatography-Time-of-Flight Mass Spectrometry 
      (UPLC-TOF-MS).
PG  - 7846-7856
LID - 10.1021/acs.jafc.8b01756 [doi]
AB  - Ultra-Performance Liquid Chromatography/electrospray ionization mass spectrometry 
      was used for the trace level determination of isopropyl methylphosphonofluoridate 
      (Sarin, GB) and ( O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate 
      (VX) after extraction from various foods. A method utilizing normal phase silica 
      gel was developed for the sample preparation and extraction of VX and GB from 
      food. The extraction efficiencies of the normal phase silica gel method for VX 
      was compared to those of other commercial solid phase extraction media and was 
      found to be comparable. Sarin was found to be incompatible with both the mixed 
      mode cation exchange (MCX) sorbents and QuEChERS methods that are commercially 
      available but was successful with the normal phase silica gel method. The linear 
      range of quantitation for VX was 0.1-330 ng/mL and for GB was 20-1200 ng/mL. The 
      average recoveries of VX and GB from the various food matrices along with the 
      corresponding relative standard deviations (RSDs) are reported.
FAU - Bae, Sue Y
AU  - Bae SY
AD  - Research and Technology Directorate , U.S. Army, Edgewood Chemical Biological 
      Center (ECBC), Aberdeen Proving Ground , Maryland 21010-5424 , United States.
FAU - Winemiller, Mark D
AU  - Winemiller MD
AUID- ORCID: 0000-0001-7433-428X
AD  - Research and Technology Directorate , U.S. Army, Edgewood Chemical Biological 
      Center (ECBC), Aberdeen Proving Ground , Maryland 21010-5424 , United States.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180711
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Chemical Warfare Agents)
RN  - 0 (Organothiophosphorus Compounds)
RN  - 60650-90-0 (Silica Gel)
RN  - 9A4381183B (VX)
RN  - B4XG72QGFM (Sarin)
SB  - IM
MH  - Animals
MH  - Chemical Warfare Agents/*chemistry/*isolation & purification
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Eggs/analysis
MH  - Food Contamination/*analysis
MH  - Fruit and Vegetable Juices/analysis
MH  - Milk/chemistry
MH  - Organothiophosphorus Compounds/*analysis/*isolation & purification
MH  - Sarin/*analysis/*isolation & purification
MH  - Silica Gel
MH  - Solid Phase Extraction/instrumentation/*methods
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - chemical warfare agents
OT  - mass spectrometry
OT  - solid phase extraction
EDAT- 2018/06/20 06:00
MHDA- 2018/08/15 06:00
CRDT- 2018/06/20 06:00
PHST- 2018/06/20 06:00 [pubmed]
PHST- 2018/08/15 06:00 [medline]
PHST- 2018/06/20 06:00 [entrez]
AID - 10.1021/acs.jafc.8b01756 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2018 Jul 25;66(29):7846-7856. doi: 10.1021/acs.jafc.8b01756. 
      Epub 2018 Jul 11.