PMID- 29921170
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20220331
IS  - 1744-8069 (Electronic)
IS  - 1744-8069 (Linking)
VI  - 14
DP  - 2018 Jan-Dec
TI  - ATF2, but not ATF3, participates in the maintenance of nerve injury-induced 
      tactile allodynia and thermal hyperalgesia.
PG  - 1744806918787427
LID - 10.1177/1744806918787427 [doi]
LID - 1744806918787427
AB  - Transcription factors are proteins that modulate the transcriptional rate of 
      target genes in the nucleus in response to extracellular or cytoplasmic signals. 
      Activating transcription factors 2 (ATF2) and 3 (ATF3) respond to environmental 
      signals and maintain cellular homeostasis. There is evidence that inflammation 
      and nerve injury modulate ATF2 and ATF3 expression. However, the function of 
      these transcription factors in pain is unknown. The purpose of this study was to 
      investigate the contribution of ATF2 and ATF3 to nerve injury-induced neuropathic 
      pain. L5/6 spinal nerve ligation induced tactile allodynia and thermal 
      hyperalgesia. Moreover, nerve damage enhanced ATF2 and ATF3 protein expression in 
      injured L5/6 dorsal root ganglia and spinal cord but not in uninjured L4 dorsal 
      root ganglia. Nerve damage also enhanced ATF2 immunoreactivity in dorsal root 
      ganglia and spinal cord 7 to 21 days post-injury. Repeated intrathecal 
      post-treatment with a small-interfering RNA targeted against ATF2 (ATF2 siRNA) or 
      anti-ATF2 antibody partially reversed tactile allodynia and thermal hyperalgesia. 
      In contrast, ATF3 siRNA or anti-ATF3 antibody did not modify nociceptive 
      behaviors. ATF2 immunoreactivity was found in dorsal root ganglia and spinal cord 
      co-labeling with NeuN mainly in non-peptidergic (IB4(+)) but also in peptidergic 
      (CGRP(+)) neurons. ATF2 was found mainly in small- and medium-sized neurons. 
      These results suggest that ATF2, but not ATF3, is found in strategic sites 
      related to spinal nociceptive processing and participates in the maintenance of 
      neuropathic pain in rats.
FAU - Salinas-Abarca, Ana B
AU  - Salinas-Abarca AB
AD  - 1 Neurobiology of Pain Laboratory, Departamento de Farmacobiologia, Cinvestav, 
      Mexico.
FAU - Velazquez-Lagunas, Isabel
AU  - Velazquez-Lagunas I
AD  - 1 Neurobiology of Pain Laboratory, Departamento de Farmacobiologia, Cinvestav, 
      Mexico.
FAU - Franco-Enzastiga, Urzula
AU  - Franco-Enzastiga U
AD  - 1 Neurobiology of Pain Laboratory, Departamento de Farmacobiologia, Cinvestav, 
      Mexico.
FAU - Torres-Lopez, Jorge E
AU  - Torres-Lopez JE
AD  - 2 Laboratorio Mecanismos del Dolor, Centro de Investigacion, Division Academica 
      de Ciencias de la Salud, Universidad Juarez Autonoma de Tabasco, Mexico.
AD  - 3 Hospital Regional de Alta Especialidad Dr. Juan Graham Casasus, Mexico.
FAU - Rocha-Gonzalez, Hector I
AU  - Rocha-Gonzalez HI
AD  - 4 Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, 
      Instituto Politecnico Nacional, Mexico.
FAU - Granados-Soto, Vinicio
AU  - Granados-Soto V
AUID- ORCID: 0000-0003-1038-8400
AD  - 1 Neurobiology of Pain Laboratory, Departamento de Farmacobiologia, Cinvestav, 
      Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180619
PL  - United States
TA  - Mol Pain
JT  - Molecular pain
JID - 101242662
RN  - 0 (Activating Transcription Factor 2)
RN  - 0 (Activating Transcription Factor 3)
RN  - 0 (Atf2 protein, rat)
RN  - 0 (Atf3 protein, rat)
RN  - 0 (Lectins)
RN  - 0 (RNA, Small Interfering)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
MH  - Activating Transcription Factor 2/genetics/*metabolism
MH  - Activating Transcription Factor 3/genetics/*metabolism
MH  - Animals
MH  - Calcitonin Gene-Related Peptide/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Ganglia, Spinal/metabolism/pathology
MH  - Gene Expression Regulation
MH  - Hyperalgesia/*etiology/*metabolism
MH  - Lectins/metabolism
MH  - Male
MH  - Microscopy, Confocal
MH  - Pain Measurement
MH  - Peripheral Nerve Injuries/complications/pathology
MH  - Phosphopyruvate Hydratase/metabolism
MH  - RNA, Small Interfering/administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Spinal Nerves/metabolism/pathology
MH  - Touch/physiology
PMC - PMC6050803
OTO - NOTNLM
OT  - ATF2
OT  - ATF3
OT  - neuropathic pain
OT  - tactile allodynia
OT  - thermal hyperalgesia
EDAT- 2018/06/21 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/06/19
CRDT- 2018/06/21 06:00
PHST- 2018/06/21 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/06/21 06:00 [entrez]
PHST- 2018/06/19 00:00 [pmc-release]
AID - 10.1177_1744806918787427 [pii]
AID - 10.1177/1744806918787427 [doi]
PST - ppublish
SO  - Mol Pain. 2018 Jan-Dec;14:1744806918787427. doi: 10.1177/1744806918787427. Epub 
      2018 Jun 19.