PMID- 29922966
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20210309
IS  - 1591-9528 (Electronic)
IS  - 1591-8890 (Linking)
VI  - 18
IP  - 4
DP  - 2018 Nov
TI  - Parathyroid carcinoma in multiple endocrine neoplasm type 1 syndrome: case report 
      and systematic literature review.
PG  - 585-593
LID - 10.1007/s10238-018-0512-7 [doi]
AB  - The aim of this report was to illustrate a case of parathyroid carcinoma (PC) in 
      a patient with multiple endocrine neoplasia type 1 (MEN1) along with a 
      comprehensive literature review. A 61-year-old man presented with 9-cm PC causing 
      primary hyperparathyroidism (PHPT). His pre-operative corrected calcium and 
      intact PTH serum levels were 2.92 mmol/L and 391.7 pg/mL, respectively. The 
      neoplastic gland was removed in bloc with thyroid and central compartment lymph 
      nodes. A literature review was run by searching PubMed MEDLINE from 1977 to 2018 
      for studies of all types, in the English language only, using the terms 
      "Parathyroid, carcinoma, Multiple endocrine neoplasia, type 1, (MEN1)." Pathology 
      confirmed PC. Post-operative calcium and PTH levels were normal. A diagnosis of 
      MEN1 was established post-operatively. Seventeen cases of PC in patients with 
      MEN1 have been reported in the literature. 59% of patients were men, and median 
      age at diagnosis was 50 years, with median serum PTH of 379 pg/mL and median 
      serum calcium level of 3.2 mmol/L. The occurrence of PC in the context of MEN1 is 
      extremely rare. Diagnosis and treatment may represent a challenge, so opportune 
      identification or suspicion of malignancy and adoption of correct surgical 
      approach may offer affected patients the best outcome.
FAU - Di Meo, Giovanna
AU  - Di Meo G
AD  - Department of Biomedical Sciences and Human Oncology - Unit of Endocrine, 
      Digestive and Emergency Surgery, University "A. Moro" of Bari. Polyclinic of 
      Bari, Piazza Giulio Cesare, 1, 70124, Bari, Italy.
FAU - Sgaramella, Lucia Ilaria
AU  - Sgaramella LI
AD  - Department of Biomedical Sciences and Human Oncology - Unit of Endocrine, 
      Digestive and Emergency Surgery, University "A. Moro" of Bari. Polyclinic of 
      Bari, Piazza Giulio Cesare, 1, 70124, Bari, Italy.
FAU - Ferraro, Valentina
AU  - Ferraro V
AD  - Department of Biomedical Sciences and Human Oncology - Unit of Endocrine, 
      Digestive and Emergency Surgery, University "A. Moro" of Bari. Polyclinic of 
      Bari, Piazza Giulio Cesare, 1, 70124, Bari, Italy.
FAU - Prete, Francesco Paolo
AU  - Prete FP
AD  - Department of Emergency and Organ Transplant, University "A. Moro" of Bari. 
      Polyclinic of Bari, Piazza Giulio Cesare, 1, 70124, Bari, Italy.
FAU - Gurrado, Angela
AU  - Gurrado A
AD  - Department of Biomedical Sciences and Human Oncology - Unit of Endocrine, 
      Digestive and Emergency Surgery, University "A. Moro" of Bari. Polyclinic of 
      Bari, Piazza Giulio Cesare, 1, 70124, Bari, Italy.
FAU - Testini, Mario
AU  - Testini M
AUID- ORCID: 0000-0002-9297-4894
AD  - Department of Biomedical Sciences and Human Oncology - Unit of Endocrine, 
      Digestive and Emergency Surgery, University "A. Moro" of Bari. Polyclinic of 
      Bari, Piazza Giulio Cesare, 1, 70124, Bari, Italy. mario.testini@uniba.it.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Systematic Review
DEP - 20180620
PL  - Italy
TA  - Clin Exp Med
JT  - Clinical and experimental medicine
JID - 100973405
RN  - 0 (PTH protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/metabolism
MH  - Comorbidity
MH  - Humans
MH  - Hyperparathyroidism, Primary/*etiology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications/metabolism
MH  - Parathyroid Hormone/metabolism
MH  - Parathyroid Neoplasms/*diagnostic imaging/metabolism/pathology/*surgery
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Cancer
OT  - MEN1
OT  - Multiple endocrine neoplasia type 1
OT  - Parathyroid carcinoma
OT  - Primary hyperparathyroidism
OT  - Surgery
EDAT- 2018/06/21 06:00
MHDA- 2019/07/02 06:00
CRDT- 2018/06/21 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/06/10 00:00 [accepted]
PHST- 2018/06/21 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
PHST- 2018/06/21 06:00 [entrez]
AID - 10.1007/s10238-018-0512-7 [pii]
AID - 10.1007/s10238-018-0512-7 [doi]
PST - ppublish
SO  - Clin Exp Med. 2018 Nov;18(4):585-593. doi: 10.1007/s10238-018-0512-7. Epub 2018 
      Jun 20.