PMID- 29923005
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20181114
IS  - 1573-8221 (Electronic)
IS  - 0007-4888 (Linking)
VI  - 165
IP  - 2
DP  - 2018 Jun
TI  - Therapeutic Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on 
      Neuroinflammation and Neuroplasticity in Patients with Parkinson's Disease: a 
      Placebo-Controlled Study.
PG  - 195-199
LID - 10.1007/s10517-018-4128-4 [doi]
AB  - The parallel placebo-controlled study examined the therapeutic effects of 
      dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor 
      cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on 
      spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory 
      cytokines by the blood cells and the level of brain-derived neurotrophic factor 
      (BDNF) in blood serum of patients with Parkinson's disease. The significantly 
      steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS 
      group in comparison with the placebo group was accompanied by a significant drop 
      in spontaneous production of proinflammatory cytokines IFNgamma and IL-17A. rTMS 
      produced no significant effect on serum BDNF. The possible mechanisms of rTMS 
      therapeutic action on the level of cytokines associated with neuroinflammation in 
      patients with Parkinson's disease are discussed.
FAU - Aftanas, L I
AU  - Aftanas LI
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia. 
      liaftanas@gmail.com.
AD  - Novosibirsk National Research State University, Novosibirsk, Russia. 
      liaftanas@gmail.com.
FAU - Gevorgyan, M M
AU  - Gevorgyan MM
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
FAU - Zhanaeva, S Ya
AU  - Zhanaeva SY
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
FAU - Dzemidovich, S S
AU  - Dzemidovich SS
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
FAU - Kulikova, K I
AU  - Kulikova KI
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
FAU - Al'perina, E L
AU  - Al'perina EL
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
FAU - Danilenko, K V
AU  - Danilenko KV
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
AD  - Novosibirsk National Research State University, Novosibirsk, Russia.
FAU - Idova, G V
AU  - Idova GV
AD  - Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
AD  - Novosibirsk National Research State University, Novosibirsk, Russia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180619
PL  - United States
TA  - Bull Exp Biol Med
JT  - Bulletin of experimental biology and medicine
JID - 0372557
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Placebos)
SB  - IM
MH  - Aged
MH  - Cytokines/blood
MH  - Double-Blind Method
MH  - Encephalitis/blood/etiology/*therapy
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Middle Aged
MH  - Neuronal Plasticity/*physiology
MH  - Parkinson Disease/blood/pathology/psychology/*therapy
MH  - Placebos
MH  - Transcranial Magnetic Stimulation/*methods
OTO - NOTNLM
OT  - BDNF
OT  - Parkinson's disease
OT  - high-frequency repetitive transcranial magnetic stimulation (rTMS)
OT  - pro- and anti-inflammatory cytokines
EDAT- 2018/06/21 06:00
MHDA- 2018/11/15 06:00
CRDT- 2018/06/21 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/06/21 06:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
PHST- 2018/06/21 06:00 [entrez]
AID - 10.1007/s10517-018-4128-4 [pii]
AID - 10.1007/s10517-018-4128-4 [doi]
PST - ppublish
SO  - Bull Exp Biol Med. 2018 Jun;165(2):195-199. doi: 10.1007/s10517-018-4128-4. Epub 
      2018 Jun 19.