PMID- 29923070
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2193-8253 (Print)
IS  - 2193-6536 (Electronic)
IS  - 2193-6536 (Linking)
VI  - 7
IP  - 2
DP  - 2018 Dec
TI  - A Systematic Review and Meta-Analysis of the Brief Cognitive Assessment for 
      Multiple Sclerosis (BICAMS).
PG  - 287-306
LID - 10.1007/s40120-018-0102-3 [doi]
AB  - Multiple sclerosis (MS) is a neurological disease of the central nervous system 
      which can lead to a range of severe physical disabilities. A large proportion of 
      those affected will experience cognitive impairment, which is associated with a 
      worse prognosis. Effective assessment of cognition in MS has been problematic due 
      to a lack of suitable scales. The Brief International Cognitive Assessment for 
      Multiple Sclerosis (BICAMS) was developed in 2010 as part of an international 
      endeavour to facilitate cognitive assessment. AIM: The aim of this systematic 
      review and meta-analysis was to synthesise the available literature published as 
      part of the BICAMS international validation protocol. METHODS: A literature 
      search conducted using PubMed, PsycINFO and Google Scholar identified 16 studies 
      for inclusion in the systematic review, 14 of which could be included in a 
      meta-analysis. RESULTS: BICAMS has been widely validated across 11 languages and 
      14 individual cultures and locations. The meta-analysis demonstrated that BICAMS 
      identified significantly reduced cognitive functioning in adults with MS compared 
      to healthy controls. This was true for all three cognitive domains assessed by 
      BICAMS: information processing speed (g = 0.943, 95% CI 0.839, 1.046, g < 0.001), 
      immediate verbal recall memory (g = 0.688, 95% CI 0.554, 0.822, p < 0.001) and 
      immediate visual recall memory (g = 0.635, 95% CI 0.534, 0.736, p < 0.001). 
      CONCLUSION: BICAMS has been widely applied across cultures and languages to 
      assess cognition in MS. BICAMS offers a feasible, cost-effective means of 
      assessing cognition in MS worldwide. Further validation studies are underway to 
      support this project.
FAU - Corfield, Freya
AU  - Corfield F
AD  - Psychology Department, Royal Holloway, University of London, Egham, Surrey, UK.
FAU - Langdon, Dawn
AU  - Langdon D
AUID- ORCID: 0000-0003-1128-7417
AD  - Psychology Department, Royal Holloway, University of London, Egham, Surrey, UK. 
      d.langdon@rhul.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180619
PL  - New Zealand
TA  - Neurol Ther
JT  - Neurology and therapy
JID - 101637818
PMC - PMC6283796
OTO - NOTNLM
OT  - BICAMS
OT  - Brief International Cognitive Assessment for Multiple Sclerosis
OT  - Cognition
OT  - Meta-analysis
OT  - Multiple sclerosis
OT  - Systematic review
EDAT- 2018/06/21 06:00
MHDA- 2018/06/21 06:01
PMCR- 2018/06/19
CRDT- 2018/06/21 06:00
PHST- 2018/05/04 00:00 [received]
PHST- 2018/06/21 06:00 [pubmed]
PHST- 2018/06/21 06:01 [medline]
PHST- 2018/06/21 06:00 [entrez]
PHST- 2018/06/19 00:00 [pmc-release]
AID - 10.1007/s40120-018-0102-3 [pii]
AID - 102 [pii]
AID - 10.1007/s40120-018-0102-3 [doi]
PST - ppublish
SO  - Neurol Ther. 2018 Dec;7(2):287-306. doi: 10.1007/s40120-018-0102-3. Epub 2018 Jun 
      19.