PMID- 29923406
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180924
LR  - 20180924
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 34
IP  - 28
DP  - 2018 Jul 17
TI  - Biorelated Polyelectrolyte Coatings Studied by in Situ Attenuated Total 
      Reflection-Fourier Transform Infrared Spectroscopy: Deposition Concepts, Wet 
      Adhesiveness, and Biomedical Applications.
PG  - 8129-8144
LID - 10.1021/acs.langmuir.8b00897 [doi]
AB  - In this conceptual contribution, thin functional coatings consisting of either 
      pure polyelectrolytes (PELs) or complexes between oppositely charged PELs at 
      model and applied substrates are outlined. Latter PEL/PEL complexes were 
      deposited by two concepts. In a first well-known concept, PEL multilayers (PEM) 
      were consecutively deposited according to the layer-by-layer (LbL) technique. In 
      a second less known concept, PEL complex (PEC) nanoparticles (NPs) preformed by 
      mixing polycation (PC) and polyanion (PA) solutions were deposited in one step. 
      Both concepts based on binary oppositely charged PELs are compared to one based 
      on a single polycation system. Examples shall be given on adhesiveness, 
      nanostructure, and biomedical applications of PEM and PEC NP coatings. In situ 
      attenuated total reflection (ATR) infrared (IR) spectroscopy, circular dichroism 
      (CD), and scanning force microscopy (SFM) were used for molecular, optical, and 
      microscopic characterization. At first, results on the adsorbed amount and wet 
      adhesiveness of pure (single-component) PEL coatings as a function of charge 
      density are given to motivate coatings of mixed oppositely charged PELs. Second, 
      the wet adhesiveness of PEM and PEC NP coatings of identical PEL compounds in 
      aqueous media varying the molar charge ratio ( n-/ n+) and the deposition step z, 
      respectively, is compared. Upon comparing the three PEL deposition concepts, it 
      is suggested that the lack or absence of excess charge at the PEL/surface 
      interface is one of the main factors for the wet adhesiveness of all pure PEL, 
      PEM, and PEC NP coatings. Finally, the potential of PEM and PEC NP coatings for 
      biomedical applications is outlined. Concerning biopassivation, PEM coatings 
      excessed or terminated by PA repel proteins with low isoelectric points. 
      Concerning bioactivation, PEM coatings loaded with antibiotics as well as PEC NP 
      coatings loaded with therapeutic bisphosphonates showed retarded, optionally 
      temperature responsive drug release for applications in acute surgery and bone 
      healing, and immunoglobulin/PEL complex coatings might open theranostic 
      applications.
FAU - Muller, Martin
AU  - Muller M
AUID- ORCID: 0000-0001-8961-4604
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V. , Hohe Str. 6 , 01069 Dresden 
      , Germany.
AD  - Technische Universitat Dresden , FR Chemie und Lebensmittelchemie , 01062 Dresden 
      , Germany.
FAU - Urban, Birgit
AU  - Urban B
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V. , Hohe Str. 6 , 01069 Dresden 
      , Germany.
FAU - Schwarz, Simona
AU  - Schwarz S
AD  - Leibniz-Institut fur Polymerforschung Dresden e.V. , Hohe Str. 6 , 01069 Dresden 
      , Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180705
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
EDAT- 2018/06/21 06:00
MHDA- 2018/06/21 06:01
CRDT- 2018/06/21 06:00
PHST- 2018/06/21 06:00 [pubmed]
PHST- 2018/06/21 06:01 [medline]
PHST- 2018/06/21 06:00 [entrez]
AID - 10.1021/acs.langmuir.8b00897 [doi]
PST - ppublish
SO  - Langmuir. 2018 Jul 17;34(28):8129-8144. doi: 10.1021/acs.langmuir.8b00897. Epub 
      2018 Jul 5.