PMID- 29923967 OWN - NLM STAT- MEDLINE DCOM- 20180807 LR - 20180807 IS - 1537-2677 (Electronic) IS - 0740-9303 (Linking) VI - 34 IP - 4 DP - 2018 Jul/Aug TI - Orbital Mass With Features of Both Kimura Disease and Immunoglobulin G4-Related Disease. PG - e121-e123 LID - 10.1097/IOP.0000000000001135 [doi] AB - Kimura disease has been known as a chronic inflammatory disease of unknown etiology, since the first report in 1937 and characterized by an increased eosinophil fraction in peripheral blood, increased serum immunoglobulin E (IgE) levels, and lymphoid granuloma with eosinophilic infiltration on histopathological examination. The authors present a 30-year-old man who visited their clinic with a 3-month history of protrusion and conjunctival injection of the right eye. Surgical mass resection was performed, and initial histopathology revealed Kimura disease. Additional immunohistochemical examination revealed IgG4-related disease in another hospital, which showed more than 80 IgG4-positive plasma cells per high-power field and an IgG4+/IgG+ ratio more than 40%. There are histopathological similarities, and several reports have suggested a relationship between Kimura disease and IgG4-related disease. Thus, it is difficult to classify them as completely different diseases. Kimura disease and IgG4 can be considered a part of a clinical spectrum of abnormal immune reactions. FAU - Lee, Jung Hyun AU - Lee JH AD - HanGil Eye Hospital, Incheon, South Korea. FAU - Kim, Jeong Hee AU - Kim JH AD - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. FAU - Lee, Sang Un AU - Lee SU AD - HanGil Eye Hospital, Incheon, South Korea. AD - Department of Ophthalmology, College of Medicine, Catholic Kwandong University, Incheon, South Korea. FAU - Kim, Sung Chul AU - Kim SC AD - HanGil Eye Hospital, Incheon, South Korea. AD - Department of Ophthalmology, College of Medicine, Catholic Kwandong University, Incheon, South Korea. LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Ophthalmic Plast Reconstr Surg JT - Ophthalmic plastic and reconstructive surgery JID - 8508431 RN - 0 (Immunoglobulin G) SB - IM MH - Adult MH - Angiolymphoid Hyperplasia with Eosinophilia/*diagnosis MH - Humans MH - Immunoglobulin G/*blood MH - Male MH - Orbital Diseases/*diagnosis EDAT- 2018/06/21 06:00 MHDA- 2018/08/08 06:00 CRDT- 2018/06/21 06:00 PHST- 2018/06/21 06:00 [pubmed] PHST- 2018/08/08 06:00 [medline] PHST- 2018/06/21 06:00 [entrez] AID - 10.1097/IOP.0000000000001135 [doi] PST - ppublish SO - Ophthalmic Plast Reconstr Surg. 2018 Jul/Aug;34(4):e121-e123. doi: 10.1097/IOP.0000000000001135.