PMID- 29924291
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20220129
IS  - 1532-4796 (Electronic)
IS  - 0883-6612 (Print)
IS  - 0883-6612 (Linking)
VI  - 53
IP  - 4
DP  - 2019 Mar 20
TI  - Happiness and Inflammatory Responses to Acute Stress in People With Type 2 
      Diabetes.
PG  - 309-320
LID - 10.1093/abm/kay039 [doi]
AB  - BACKGROUND: Positive psychological characteristics in people with type 2 diabetes 
      (T2D) are associated with better health and longevity, and one plausible 
      physiological mechanism involves lower markers of inflammation. Positive affect 
      is related to lower basal inflammatory markers and smaller inflammatory responses 
      to acute stress, but this association in people with T2D remains to be examined. 
      PURPOSE: To examine the relationship between happiness and inflammatory markers 
      at baseline and in response to acute stress in people with T2D. METHODS: One 
      hundred forty people with T2D took part in laboratory-based stress testing. We 
      aggregated daily happiness ratings over 7 days before stress testing. During the 
      laboratory session, participants underwent two mental stress tasks-the mirror 
      tracing and the Stroop task. Blood was sampled at baseline and post-stress (up to 
      75 min post-stress) to detect plasma interleukin-6 (IL-6), interleukin-1 receptor 
      antagonist (IL-1Ra), and monocyte chemoattractant protein-1 (MCP-1). Associations 
      between happiness and inflammatory markers and responses were analyzed using 
      multivariable linear regressions. RESULTS: Greater daily happiness significantly 
      predicted lower baseline and post-stress IL-6 concentrations, and lower baseline 
      MCP-1, after adjusting for covariates. The association between happiness and 
      reduced basal IL-6 maintained after further controlling for daily sadness. We did 
      not find significant associations between daily happiness and inflammatory 
      responses to acute stress. No associations were detected for IL-1Ra. CONCLUSIONS: 
      Happier individuals with T2D have lower inflammatory markers before and after 
      acute stress, albeit independent of stress responsivity. Findings could provide a 
      protective physiological pathway linking daily happiness with better health in 
      people with T2D.
CI  - (c) The Author(s) 2018. Published by Oxford University Press on behalf of the 
      Society of Behavioral Medicine.
FAU - Panagi, Laura
AU  - Panagi L
AD  - Research Department of Behavioral Science and Health, University College London, 
      London, UK.
FAU - Poole, Lydia
AU  - Poole L
AD  - Research Department of Behavioral Science and Health, University College London, 
      London, UK.
FAU - Hackett, Ruth A
AU  - Hackett RA
AD  - Research Department of Behavioral Science and Health, University College London, 
      London, UK.
FAU - Steptoe, Andrew
AU  - Steptoe A
AD  - Research Department of Behavioral Science and Health, University College London, 
      London, UK.
LA  - eng
GR  - RG/10/005/28296/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Behav Med
JT  - Annals of behavioral medicine : a publication of the Society of Behavioral 
      Medicine
JID - 8510246
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Diabetes Mellitus, Type 2/blood/*complications/psychology
MH  - Female
MH  - *Happiness
MH  - Humans
MH  - Inflammation/blood/*etiology/psychology
MH  - Interleukin 1 Receptor Antagonist Protein/*blood
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Personality/physiology
MH  - Stress, Psychological/blood/*complications/psychology
PMC - PMC6426003
OTO - NOTNLM
OT  - Happiness
OT  - Inflammatory markers
OT  - Mental stress
OT  - Stress responses
OT  - Type 2 diabetes
EDAT- 2018/06/21 06:00
MHDA- 2020/05/12 06:00
PMCR- 2018/06/18
CRDT- 2018/06/21 06:00
PHST- 2018/06/21 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2018/06/21 06:00 [entrez]
PHST- 2018/06/18 00:00 [pmc-release]
AID - 5039982 [pii]
AID - kay039 [pii]
AID - 10.1093/abm/kay039 [doi]
PST - ppublish
SO  - Ann Behav Med. 2019 Mar 20;53(4):309-320. doi: 10.1093/abm/kay039.