PMID- 29926589
OWN - NLM
STAT- MEDLINE
DCOM- 20181119
LR  - 20200930
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 33
IP  - 5
DP  - 2017 May 8
TI  - [Effects of weight-bearing ladder and aerobic treadmill exercise on learning and 
      memory ability of diabetic rats and its mechanism].
PG  - 436-440
LID - 10.12047/j.cjap.5570.2017.105 [doi]
AB  - OBJECTIVE: To investigate the effects of climb ladder and aerobic treadmill 
      exercise on learning memory ability in diabetic rats and explore its possible 
      mechanisms. METHODS: Forty male rats were randomly divided into normal control 
      group (NC), diabetic control group (DC), diabetic loading ladder group (DL) and 
      diabetic aerobic treadmill group (DA), diabetes was induced by a single 
      intraperitoneal injection of STZ. In the evening, the DL group were trained three 
      cycle (10 times/cycle) with weight-bearing climbing ladder, 2 min intervals, 6 
      days/week, lasted for six weeks. The DA group was trained on a motor-driven 
      treadmill at a speed of 20 m/min (0 incline), 30 min/day, 6 days/week, lasted for 
      six weeks. Morris water maze was used to detect the learning and memory ability 
      of rats after modeling success and after exercise intervention. After the last 
      water maze test, the rats were killed to obtain the hippocampus. RT-QPCR was used 
      to detect the gene expressions of brain derived neurophic factor (BDNF), 
      tropomyosin receptor kinase B (TrkB) and cAMP-response element binding protein 
      (CREB). RESULTS: Compared with NC group, the expressions of BDNF and CREB gene in 
      hippocampus of DC group and the learning and memory ability were significantly 
      decreased. Compared with DC group, the expression of BDNF and CREB in hippocampus 
      of DL and DA rats was significantly up-regulated and the learning ability was 
      significantly increased. The TrkB gene of hippocampus in DL rats was 
      significantly up-regulated and the spatial memory ability was significantly 
      improved. Compared with the DA group, the TRKB and CREB genes in the hippocampus 
      of DL group were significantly up-regulated. CONCLUSIONS: Aerobic treadmill 
      exercise and weight-bearing ladder exercise have a positive effect on the 
      learning ability of diabetic rats, while the weight-bearing ladder exercise 
      improves the memory ability of diabetic rats better than aerobic exercise. These 
      effects may be related to the up-regulation of BDNF/TrkB/CREB signaling pathway.
FAU - Tang, Liang
AU  - Tang L
AD  - Institutie of Physical Education, Shanxi Normal University, Xi'an 710119, China.
FAU - Kang, Yi-Ting
AU  - Kang YT
AD  - Institutie of Physical Education, Shanxi Normal University, Xi'an 710119, China.
FAU - Yin, Bo
AU  - Yin B
AD  - Institutie of Physical Education, Shanxi Normal University, Xi'an 710119, China.
FAU - Sun, Li-Jun
AU  - Sun LJ
AD  - Institutie of Physical Education, Shanxi Normal University, Xi'an 710119, China.
FAU - Fan, Xiu-Shan
AU  - Fan XS
AD  - Institutie of Physical Education, Shanxi Normal University, Xi'an 710119, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 135844-64-3 (Cyclic AMP Response Element Modulator)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cyclic AMP Response Element Modulator/metabolism
MH  - *Diabetes Mellitus, Experimental
MH  - Hippocampus/metabolism
MH  - *Learning
MH  - Male
MH  - *Memory
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Receptor, trkB/metabolism
MH  - *Weight-Bearing
OTO - NOTNLM
OT  - BDNF
OT  - aerobic treadmill exercise
OT  - diabetes
OT  - learning and memory
OT  - rats
OT  - weight-bearing ladder exercise
EDAT- 2018/06/22 06:00
MHDA- 2018/11/20 06:00
CRDT- 2018/06/22 06:00
PHST- 2018/06/22 06:00 [entrez]
PHST- 2018/06/22 06:00 [pubmed]
PHST- 2018/11/20 06:00 [medline]
AID - 10.12047/j.cjap.5570.2017.105 [doi]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2017 May 8;33(5):436-440. doi: 
      10.12047/j.cjap.5570.2017.105.