PMID- 29926637
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20181114
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 33
IP  - 4
DP  - 2017 Apr 8
TI  - [The effects of dihydromyricetin on cognitive dysfunction in type 2 diabetes 
      mice].
PG  - 323-328
LID - 10.12047/j.cjap.5478.2017.079 [doi]
AB  - OBJECTIVE: To observe the effects of dihydromyricetin(DHM) on cognitive 
      dysfunction and expression of brain derived neurotrophic factor(BDNF) protein in 
      hippocampus of type 2 diabetic mice(T2DM). METHODS: Forty C57BL/6J mice were 
      randomly divided into two groups, normal control group (n=8):normal diet feeding; 
      T2DM model group (n=32):high-glucose and high-fat combined with 100 mg/kg 
      streptozocin(STZ) treatment (five mice died during modeling and three failed). 
      Twenty-four diabetic mice were modeled successfully and divided into three groups 
      (T2DM group, T2DM+L-DHM group and T2DM+H-DHM group). Three groups mice were fed 
      with high-glucose and high-fat diet, and treated with equal volume of normal 
      saline, 125 mg/(kg.d) DHM or 250 mg/(kg.d) DHM for 16 weeks respectively. The 
      control mice were fed with normal diet and treated with equal volume of saline 
      (once a day, gavage) for 16 weeks. After 16 weeks, the body weight and fasting 
      blood glucose were measured, intraperitoneal glucose tolerance test and related 
      behavioral experiment were performed. Finally, the expression of BDNF protein in 
      hippocampus of mice was detected by Western blot. RESULTS: The model of type 2 
      diabetes mellitus was established successfully with high-glucose and high-fat 
      combined with 100 mg/kg STZ. After 16 weeks, the body weight of T2DM group was 
      significantly decreased, the fasting blood glucose was significantly increased 
      and the glucose tolerance was significantly abnormal compared with the normal 
      control group. Compared with T2DM group, the body weight of T2DM+DHM groups mice 
      was increased, while the levels of fasting blood glucose were decreased. And 
      H-DHM could significantly improve the abnormal glucose tolerance of T2DM mice. 
      Behavior test results showed that the ability of learning and memory of T2DM mice 
      was significant decreased compared with control group, but these phenomena were 
      improved in T2DM+DHM groups mice, and T2DM+H-DHM group was more obvious. Western 
      blot analysis showed that the expression of BDNF protein in hippocampus of T2DM 
      group was significantly lower than that of control group, while T2DM+DHM group 
      was significant increased compared with T2DM mice. CONCLUSIONS: Dihydromyricetin 
      can improve the cognitive dysfunction in type 2 diabetic mice. The mechanism may 
      be through hypoglycemic effect and activation of BDNF protein expression in 
      hippocampus.
FAU - Zhu, Ze-Mei
AU  - Zhu ZM
AD  - Department of Medicine, Changde Vocational Technical College, Changde 415003.
AD  - Department of Physiology, University of South China, University of South China, 
      Hengyang 421001, China.
FAU - Yang, Ji-Hua
AU  - Yang JH
AD  - Department of Physiology, University of South China, University of South China, 
      Hengyang 421001, China.
FAU - Yang, Si-Si
AU  - Yang SS
AD  - Department of Physiology, University of South China, University of South China, 
      Hengyang 421001, China.
FAU - He, Jian-Qin
AU  - He JQ
AD  - Department of Physiology, University of South China, University of South China, 
      Hengyang 421001, China.
FAU - Zhang, Kai-Fang
AU  - Zhang KF
AD  - Department of Physiology, University of South China, University of South China, 
      Hengyang 421001, China.
FAU - Feng, Shui-Dong
AU  - Feng SD
AD  - Department of Social Medicine and Health Service Management, University of South 
      China, Hengyang 421001, China.
FAU - Ling, Hong-Yan
AU  - Ling HY
AD  - Department of Physiology, University of South China, University of South China, 
      Hengyang 421001, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonols)
RN  - KD8QND6427 (dihydromyricetin)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognitive Dysfunction/*drug therapy
MH  - Diabetes Mellitus, Experimental/complications
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Flavonols/*pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Learning/drug effects
MH  - Memory/drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
OTO - NOTNLM
OT  - BDNF
OT  - cognitive impairment
OT  - dihydromyricetin
OT  - mouse
OT  - type 2 diabetes
EDAT- 2017/04/08 00:00
MHDA- 2018/11/15 06:00
CRDT- 2018/06/22 06:00
PHST- 2018/06/22 06:00 [entrez]
PHST- 2017/04/08 00:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
AID - 10.12047/j.cjap.5478.2017.079 [doi]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2017 Apr 8;33(4):323-328. doi: 
      10.12047/j.cjap.5478.2017.079.