PMID- 29926656
OWN - NLM
STAT- MEDLINE
DCOM- 20190104
LR  - 20211204
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 34
IP  - 1
DP  - 2018 Jan 8
TI  - [cts of prenatal exposure of 850-1900MHz mobile phone on the expression of PCNA 
      and DCX in dentate gyrus of offspring rats].
PG  - 35-38
LID - 10.12047/j.cjap.5592.2018.010 [doi]
AB  - OBJECTIVE: To evaluate the effect of prenatal mobile phone exposure on the 
      expression of proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) in 
      dentate gyrus of offspring rats. METHODS: The rat model of prenatal mobile phone 
      exposure was established and there were three groups including control group, 
      short term maternal exposure group and long term maternal exposure group(n=6). 
      From pregnant day 1 to day 17, pregnant rats in long term and short term maternal 
      exposure group were exposed to an mobile phone in talking mode for 6 h/d and 24 
      h/d, respectively. Length of pregnancy, maternal body weight gain, litter size 
      and pup's body weight were observed. The cell morphology in dentate gyrus of 
      offspring rats at the age of 1 month was studied by cresyl violet staining. The 
      immunohistochemical expression of PCNA and DCX in dentate gyrus of rat offspring 
      were detected, and the expression of DCX and brain derived neurotrophic factor 
      (BDNF) in hippocampus of rat offspring were evaluated by Western blot. RESULTS: 
      There was no difference in length of pregnancy, maternal body weight gain, litter 
      size and pup's body weight among three groups. The morphological changes of 
      pyramidal cells in the polymorphic layer and DCX-positive cells in the dentate 
      gyrus were obvious in rat offspring of long term maternal exposure group. There 
      were less PCNA-positive cells in dentate gyrus and decreased expression of DCX 
      and BDNF in hippocampus by Western blot in long term maternal exposure group 
      compared with control and short term maternal exposure group (all P<0.05). 
      CONCLUSIONS: Long term prenatal mobile phone exposure might inhibit the 
      expression of PCNA and DCX in dentate gyrus of rat offspring by down-regulating 
      BDNF.
FAU - Wang, Ling-Xing
AU  - Wang LX
AD  - Department of Neurology, the Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou 362000, China.
FAU - Huang, Hong-Hong
AU  - Huang HH
AD  - Department of Neurology, the Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou 362000, China.
FAU - Lv, Guo-Rong
AU  - Lv GR
AD  - Department of Ultrasound, the Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou 362000, China.
AD  - Department of Clinical Medicine, Quanzhou Medical College, Quanzhou 362000, 
      China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Domain Proteins)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - *Cell Phone
MH  - Dentate Gyrus/*metabolism
MH  - Doublecortin Domain Proteins
MH  - Doublecortin Protein
MH  - Female
MH  - Hippocampus/metabolism
MH  - Microtubule-Associated Proteins/*metabolism
MH  - Neuropeptides/*metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Proliferating Cell Nuclear Antigen/*metabolism
MH  - *Radio Waves
MH  - Rats
OTO - NOTNLM
OT  - DCX
OT  - PCNA
OT  - offspring rats
OT  - prenatal mobile phone exposure
EDAT- 2018/06/22 06:00
MHDA- 2019/01/05 06:00
CRDT- 2018/06/22 06:00
PHST- 2018/06/22 06:00 [entrez]
PHST- 2018/06/22 06:00 [pubmed]
PHST- 2019/01/05 06:00 [medline]
AID - 10.12047/j.cjap.5592.2018.010 [doi]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Jan 8;34(1):35-38. doi: 
      10.12047/j.cjap.5592.2018.010.