PMID- 29926815
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 13
IP  - 6
DP  - 2018 Jun
TI  - Neurological complications of hematopoietic cell transplantation in children and 
      adults.
PG  - 945-954
LID - 10.4103/1673-5374.233431 [doi]
AB  - Hematopoietic cell transplantation (HCT) is widely performed for neoplastic and 
      non-neoplastic diseases. HCT involves intravenous infusion of hematopoietic 
      progenitor cells from human leukocyte antigen (HLA)-matched donor (allogeneic) or 
      from the patient (autologous). Before HCT, the patient is prepared with high dose 
      chemotherapy and/or radiotherapy to destroy residual malignant cells and to 
      reduce immunologic resistance. After HCT, chemotherapy is used to prevent graft 
      rejection and graft versus host disease (GvHD). Neurological complications are 
      related to the type of HCT, underlying disease, toxicity of the conditioning 
      regimens, immunosuppression caused by conditioning regimens, vascular 
      complications generated by thrombocytopenia and/or coagulopathy, GvHD and 
      inappropriate immune response. In this review, neurological complications are 
      presented according to time of onset after HCT: (1) early complications (in the 
      first month) - related to harvesting of stem cells, during conditioning (drug 
      toxicity, posterior reversible encephalopathy syndrome), related to pancytopenia, 
      (2) intermediate phase complications (second to sixth month) - central nervous 
      system infections caused by prolonged neutropenia and progressive multifocal 
      leukoencephalopathy due to JC virus, (3) late phase complications (after sixth 
      month) - neurological complications of GvHD, second neoplasms and relapses of the 
      original disease.
FAU - Dulamea, Adriana Octaviana
AU  - Dulamea AO
AD  - University of Medicine and Pharmacy Carol Davila; Department of Neurology, 
      Fundeni Clinical Institute, Bucharest, Romania.
FAU - Lupescu, Ioana Gabriela
AU  - Lupescu IG
AD  - University of Medicine and Pharmacy Carol Davila; Radiology and Medical Imaging 
      Department, Fundeni Clinical Institute, Bucharest, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC6022482
OTO - NOTNLM
OT  - central nervous system infections
OT  - drug reaction with eosinophilia and systemic symptoms
OT  - graft versus host disease
OT  - hematopoietic cell transplantation
OT  - immune reconstitution inflammatory syndrome
OT  - neurological complications
OT  - post-transplant acute limbic encephalitis
OT  - posterior reversible encephalopathy syndrome
OT  - progressive multifocal leukoencephalopathy
OT  - second neoplasm
COIS- None declared
EDAT- 2018/06/22 06:00
MHDA- 2018/06/22 06:01
PMCR- 2018/06/01
CRDT- 2018/06/22 06:00
PHST- 2018/06/22 06:00 [entrez]
PHST- 2018/06/22 06:00 [pubmed]
PHST- 2018/06/22 06:01 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - NeuralRegenRes_2018_13_6_945_233431 [pii]
AID - NRR-13-945 [pii]
AID - 10.4103/1673-5374.233431 [doi]
PST - ppublish
SO  - Neural Regen Res. 2018 Jun;13(6):945-954. doi: 10.4103/1673-5374.233431.