PMID- 29927468
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20190314
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 49
IP  - 6
DP  - 2018 Jun 1
TI  - Reproducibility of Macular Thickness Measurements in Eyes Affected by Dry 
      Age-Related Macular Degeneration From Two Different SD-OCT Instruments.
PG  - 410-415
LID - 10.3928/23258160-20180601-05 [doi]
AB  - BACKGROUND AND OBJECTIVE: To compare macular thickness measurement algorithms of 
      two different spectral-domain optical coherence tomography (SD-OCT) devices in 
      eyes affected by dry age-related macular degeneration (AMD). PATIENTS AND 
      METHODS: Patients with dry AMD and healthy volunteers from the retina clinic of 
      the Doheny Eye Center - UCLA were imaged using two different SD-OCT devices: the 
      RS-3000 Advance (Nidek, Padova, Italy) and the Cirrus HD-OCT (Carl Zeiss Meditec, 
      Dublin, CA). All patients had been previously diagnosed with drusen or geographic 
      atrophy due to AMD. The commercial instrument software was used to generate the 
      macular retinal thickness measurements, and measurements were compared between 
      devices. RESULTS: Eighty-five diseased eyes from 49 patients and 16 healthy 
      control eyes from eight normal volunteers were included in this study. The 
      macular thickness measurements generated by the two instruments in eyes with AMD 
      differed significantly in mean retinal thickness in the foveal center subfield 
      (257.34 mum +/- 51.72 mum using the Nidek OCT vs. 238.20 mum +/- 51.89 mum using the 
      Cirrus OCT; P < .001). The mean difference in macular thickness between the two 
      devices was 19.14 mum +/- 5.84 mum for diseased eyes and 17.06 mum +/- 5.28 mum in normal 
      control eyes, and this was not statistically different between the two groups (P 
      > .05). The macular thickness measurements in diseased eyes, as evaluated by the 
      two different instruments, however, showed excellent correlation (r = 0.99; P < 
      .001), with an intraclass correlation coefficient of 0.99 (95% confidence 
      interval, 0.98-0.99). Post hoc evaluation of cases with larger differences also 
      showed differences in foveal center selection and variabilities in boundary 
      selection with specific pathology. CONCLUSION: Macular thickness measurements 
      provided by the Nidek and Cirrus OCT instruments in eyes with dry AMD are highly 
      correlated but show a consistent difference, which may allow the use of a 
      standard correction factor to be applied to better interrelate measurements 
      between the devices. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:410-415.].
CI  - Copyright 2018, SLACK Incorporated.
FAU - Tepelus, Tudor C
AU  - Tepelus TC
FAU - Hariri, Amir H
AU  - Hariri AH
FAU - Balasubramanian, Siva
AU  - Balasubramanian S
FAU - Sadda, SriniVas R
AU  - Sadda SR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Geographic Atrophy/pathology
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Macular Degeneration/*pathology
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
EDAT- 2018/06/22 06:00
MHDA- 2019/03/15 06:00
CRDT- 2018/06/22 06:00
PHST- 2017/07/06 00:00 [received]
PHST- 2017/11/02 00:00 [accepted]
PHST- 2018/06/22 06:00 [entrez]
PHST- 2018/06/22 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
AID - 10.3928/23258160-20180601-05 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2018 Jun 1;49(6):410-415. doi: 
      10.3928/23258160-20180601-05.