PMID- 29927631
OWN - NLM
STAT- MEDLINE
DCOM- 20191009
LR  - 20191010
IS  - 1552-3365 (Electronic)
IS  - 0363-5465 (Linking)
VI  - 46
IP  - 9
DP  - 2018 Jul
TI  - Therapeutic Effects of the Addition of Platelet-Rich Plasma to Bioimplants and 
      Early Rehabilitation Exercise on Articular Cartilage Repair.
PG  - 2232-2241
LID - 10.1177/0363546518780955 [doi]
AB  - BACKGROUND: Treating articular cartilage lesions is clinically challenging. 
      However, whether the addition of autologous platelet-rich plasma (PRP) to 
      bioimplants along with early rehabilitation exercise provides therapeutic effects 
      and regenerates the osteochondral defect remains uninvestigated. HYPOTHESIS: The 
      addition of PRP to a polylactic-co-glycolic acid (PLGA) scaffold along with 
      continuous passive motion (CPM) in osteochondral defects may offer beneficial in 
      situ microenvironment changes to facilitate hyaline cartilage and subchondral 
      bone tissue repair. STUDY DESIGN: Controlled laboratory study. METHODS: In 26 
      rabbits, 52 critical osteochondral defects were created in bilateral femoral 
      trochlear grooves. The rabbits were allocated to 1 of the following 3 groups: PRP 
      gel (PG group), PRP + PLGA scaffold (PP group), and PRP + PLGA scaffold + CPM 
      (PPC group). At 4 and 12 weeks after surgery, the specimens were assessed by a 
      macroscopic examination, a histological evaluation with immunohistochemical 
      staining, and micro-computed tomography. RESULTS: The PPC group exhibited the 
      most favorable therapeutic outcomes in terms of hyaline cartilage regeneration. 
      At week 4, the PPC group exhibited significantly higher levels of 
      glycosaminoglycan (GAG) and collagen (COL) II and modest increases in COL I, 
      matrix metalloproteinase-3 (MMP-3), and inflammatory cells with tumor necrosis 
      factor-alpha (TNF-alpha) and interleukin-6 (IL-6). At week 12, the PPC group had 
      significantly higher tissue repair scores, corresponding to a sound articular 
      cartilage surface and chondrocyte and collagen arrangement. This group 
      demonstrated restored hyaline cartilage and mineralized bone volume per tissue 
      volume, which had an integrating structure in the repair site. However, the PG 
      and PP groups exhibited mainly fibrous tissue and fibrocartilage, corresponding 
      to higher expressions of COL I, TNF-alpha, IL-6, and MMP-3. CONCLUSION: PRP with a 
      PLGA graft along with early CPM exercise is promising for the repair of 
      osteochondral defects in rabbit knee joints. CLINICAL RELEVANCE: This study 
      demonstrates the efficacy of a triad therapy involving the addition of PRP to 
      bioimplants along with early CPM intervention for hyaline cartilage and 
      subchondral regeneration. However, PRP alone (with or without PLGA implants) is 
      limited to osteochondral defect repair without significant regeneration.
FAU - Chang, Nai-Jen
AU  - Chang NJ
AD  - Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung City, 
      Taiwan.
FAU - Erdenekhuyag, Yanjmaa
AU  - Erdenekhuyag Y
AD  - Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung City, 
      Taiwan.
FAU - Chou, Pei-Hsi
AU  - Chou PH
AD  - Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung City, 
      Taiwan.
FAU - Chu, Chih-Jou
AU  - Chu CJ
AD  - Department of Sports Medicine, Kaohsiung Medical University, Kaohsiung City, 
      Taiwan.
FAU - Lin, Chih-Chan
AU  - Lin CC
AD  - Laboratory Animal Center, Department of Medical Research, Chi Mei Medical Center, 
      Tainan City, Taiwan.
FAU - Shie, Ming-You
AU  - Shie MY
AD  - 3D Printing Medical Research Center, China Medical University Hospital, Taichung 
      City, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180621
PL  - United States
TA  - Am J Sports Med
JT  - The American journal of sports medicine
JID - 7609541
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
SB  - IM
MH  - Animals
MH  - Cartilage, Articular/*injuries
MH  - *Exercise Therapy
MH  - Femur/injuries
MH  - Male
MH  - Models, Animal
MH  - Platelet-Rich Plasma/*physiology
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/*therapeutic use
MH  - Rabbits
MH  - Tissue Scaffolds/*statistics & numerical data
MH  - Wound Healing/*physiology
OTO - NOTNLM
OT  - PRP
OT  - cartilage
OT  - inflammation
OT  - knee
OT  - physical therapy
OT  - scaffold
EDAT- 2018/06/22 06:00
MHDA- 2019/10/11 06:00
CRDT- 2018/06/22 06:00
PHST- 2018/06/22 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
PHST- 2018/06/22 06:00 [entrez]
AID - 10.1177/0363546518780955 [doi]
PST - ppublish
SO  - Am J Sports Med. 2018 Jul;46(9):2232-2241. doi: 10.1177/0363546518780955. Epub 
      2018 Jun 21.