PMID- 29928868
OWN - NLM
STAT- MEDLINE
DCOM- 20180807
LR  - 20180807
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Linking)
VI  - 441
IP  - 1
DP  - 2018 Sep 1
TI  - The transcription factor Tfap2e/AP-2epsilon plays a pivotal role in maintaining the 
      identity of basal vomeronasal sensory neurons.
PG  - 67-82
LID - S0012-1606(18)30117-9 [pii]
LID - 10.1016/j.ydbio.2018.06.007 [doi]
AB  - The identity of individual neuronal cell types is defined and maintained by the 
      expression of specific combinations of transcriptional regulators that control 
      cell type-specific genetic programs. The epithelium of the vomeronasal organ of 
      mice contains two major types of vomeronasal sensory neurons (VSNs): 1) the 
      apical VSNs which express vomeronasal 1 receptors (V1r) and the G-protein subunit 
      Galphai2 and; 2) the basal VSNs which express vomeronasal 2 receptors (V2r) and the 
      G-protein subunit Galphao. Both cell types originate from a common pool of 
      progenitors and eventually acquire apical or basal identity through largely 
      unknown mechanisms. The transcription factor AP-2epsilon, encoded by the Tfap2e gene, 
      plays a role in controlling the development of GABAergic interneurons in the main 
      and accessory olfactory bulb (AOB), moreover AP-2epsilon has been previously described 
      to be expressed in the basal VSNs. Here we show that AP-2epsilon is expressed in 
      post-mitotic VSNs after they commit to the basal differentiation program. Loss of 
      AP-2epsilon function resulted in reduced number of basal VSNs and in an increased 
      number of neurons expressing markers of the apical lineage. Our work suggests 
      that AP-2epsilon, which is expressed in late phases of differentiation, is not needed 
      to initiate the apical-basal differentiation dichotomy but for maintaining the 
      basal VSNs' identity. In AP-2epsilon mutants we observed a large number of cells that 
      entered the basal program can express apical genes, our data suggest that 
      differentiated VSNs of mice retain a notable level of plasticity.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Lin, Jennifer M
AU  - Lin JM
AD  - Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.
FAU - Taroc, Ed Zandro M
AU  - Taroc EZM
AD  - Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.
FAU - Frias, Jesus A
AU  - Frias JA
AD  - Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.
FAU - Prasad, Aparna
AU  - Prasad A
AD  - Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.
FAU - Catizone, Allison N
AU  - Catizone AN
AD  - Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.
FAU - Sammons, Morgan A
AU  - Sammons MA
AD  - Department of Biological Sciences, University at Albany, Albany, NY 12222, USA.
FAU - Forni, Paolo E
AU  - Forni PE
AD  - Department of Biological Sciences, University at Albany, Albany, NY 12222, USA. 
      Electronic address: pforni@albany.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180619
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Transcription Factor AP-2)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - GABAergic Neurons/*metabolism
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Mutation
MH  - Nasal Mucosa/cytology/*embryology
MH  - Sensory Receptor Cells/cytology/*metabolism
MH  - Transcription Factor AP-2/*biosynthesis/genetics
MH  - Vomeronasal Organ/cytology/*embryology
EDAT- 2018/06/22 06:00
MHDA- 2018/08/08 06:00
CRDT- 2018/06/22 06:00
PHST- 2018/02/13 00:00 [received]
PHST- 2018/05/22 00:00 [revised]
PHST- 2018/06/13 00:00 [accepted]
PHST- 2018/06/22 06:00 [pubmed]
PHST- 2018/08/08 06:00 [medline]
PHST- 2018/06/22 06:00 [entrez]
AID - S0012-1606(18)30117-9 [pii]
AID - 10.1016/j.ydbio.2018.06.007 [doi]
PST - ppublish
SO  - Dev Biol. 2018 Sep 1;441(1):67-82. doi: 10.1016/j.ydbio.2018.06.007. Epub 2018 
      Jun 19.