PMID- 29928887
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 194
DP  - 2018 Oct 1
TI  - Lipopolysaccharide-mediated inflammatory priming potentiates painful 
      post-traumatic trigeminal neuropathy.
PG  - 497-504
LID - S0031-9384(18)30371-8 [pii]
LID - 10.1016/j.physbeh.2018.06.021 [doi]
AB  - We explored the molecular and behavioral effects of a perineural 
      Lipopolysaccharide (LPS)-mediated inflammatory priming on the development and 
      maintenance of painful post-traumatic trigeminal neuropathy (PPTTN) following 
      infra-orbital nerve chronic constriction injury (CCI-IoN) in rats. Rats were 
      pretreated with repetitive perineural injections in the vicinity of the IoN of 
      either LPS or vehicle (Vhcl) before being submitted to CCI-IoN. Orofacial 
      pain-like behaviors (response to Von Frey Filament testing and spontaneous 
      isolated face grooming) were measured during the period of LPS injections (three 
      weeks) and following CCI-IoN surgery (two weeks). Local LPS administration 
      induced an early pain-like behavior (i.e. an increase in spontaneous pain [SP] or 
      mechanical static allodynia [MSA]) in both conditions, and following CCI-IoN, MSA 
      and SP developed earlier and more severely in LPS-pretreated rats than in the 
      control group. Ipsilateral increases of key neuropathic pain mRNA markers in the 
      IoN parenchyma, trigeminal ganglia (TG) and spinal trigeminal nucleus caudalis 
      (Sp5C) were observed in CCI-IoN injured animals as compared to controls. Although 
      no significant molecular differences could be observed within the IoN parenchyma 
      between LPS and Vhcl-pretreated animals, a significant increase of key 
      inflammatory cytokine Interleukin 1 beta (IL - 1beta) could be found in the TG of 
      LPS-pretreated CCI-injured animals versus controls. Finally, a higher increase of 
      inducible nitric oxide synthase (iNOS) in ipsilateral Sp5C of LPS-pretreated 
      animals was observed as compared to Sp5C of Vhcl-pretreated animals. These 
      results suggest a key role of inflammatory priming in the development and 
      maintenance of PPTTN implicating IL-1beta/iNOS-dependent central sensitization 
      mechanisms.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Boucher, Yves
AU  - Boucher Y
AD  - Laboratoire de Neurobiologie Orofaciale, UFR d'Odontologie, Universite Paris 
      Diderot, Paris, France; Hopital Universitaire Pitie-Salpetriere, AP-HP, Paris, 
      France; Centre de Psychiatrie et Neurosciences, INSERM U894, Universite Paris 
      Descartes, Hopital Sainte-Anne, Paris, France.
FAU - Moreau, Nathan
AU  - Moreau N
AD  - Laboratoire de Neurobiologie Orofaciale, UFR d'Odontologie, Universite Paris 
      Diderot, Paris, France; Centre de Psychiatrie et Neurosciences, INSERM U894, 
      Universite Paris Descartes, Hopital Sainte-Anne, Paris, France; UFR 
      d'Odontologie, Universite Paris Descartes, Hopital Bretonneau, AP-HP, Paris, 
      France.
FAU - Mauborgne, Annie
AU  - Mauborgne A
AD  - Centre de Psychiatrie et Neurosciences, INSERM U894, Universite Paris Descartes, 
      Hopital Sainte-Anne, Paris, France.
FAU - Dieb, Wisam
AU  - Dieb W
AD  - Laboratoire de Neurobiologie Orofaciale, UFR d'Odontologie, Universite Paris 
      Diderot, Paris, France; Hopital Universitaire Pitie-Salpetriere, AP-HP, Paris, 
      France; Centre de Psychiatrie et Neurosciences, INSERM U894, Universite Paris 
      Descartes, Hopital Sainte-Anne, Paris, France. Electronic address: 
      wisamdieb@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180619
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
SB  - IM
MH  - Animals
MH  - Hyperalgesia/complications/physiopathology
MH  - Inflammation/chemically induced/complications/*physiopathology
MH  - Interleukin-1beta/metabolism
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - Maxillary Nerve/metabolism/*physiopathology
MH  - Neuralgia/complications/metabolism/*physiopathology
MH  - Nitric Oxide Synthase Type II/metabolism
MH  - Pain Measurement
MH  - Peripheral Nerve Injuries/complications/physiopathology
MH  - Rats
MH  - Trigeminal Ganglion/metabolism
MH  - Trigeminal Nerve Injuries/complications/metabolism/*physiopathology
MH  - Trigeminal Nucleus, Spinal/metabolism
OTO - NOTNLM
OT  - CCI-IoN
OT  - Interleukin 1 beta
OT  - LPS
OT  - Neuroinflammation
OT  - Orofacial pain
OT  - iNOS
EDAT- 2018/06/22 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/06/22 06:00
PHST- 2018/05/08 00:00 [received]
PHST- 2018/06/11 00:00 [revised]
PHST- 2018/06/14 00:00 [accepted]
PHST- 2018/06/22 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/06/22 06:00 [entrez]
AID - S0031-9384(18)30371-8 [pii]
AID - 10.1016/j.physbeh.2018.06.021 [doi]
PST - ppublish
SO  - Physiol Behav. 2018 Oct 1;194:497-504. doi: 10.1016/j.physbeh.2018.06.021. Epub 
      2018 Jun 19.