PMID- 29929419
OWN - NLM
STAT- MEDLINE
DCOM- 20191009
LR  - 20191010
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 14
IP  - 7
DP  - 2018
TI  - CMA restricted to mammals and birds: myth or reality?
PG  - 1267-1270
LID - 10.1080/15548627.2018.1460021 [doi]
AB  - Chaperone-mediated autophagy (CMA) is a major pathway of lysosomal proteolysis 
      essential for the control of intermediary metabolism. So far, the absence of any 
      identifiable LAMP2A - a necessary and limiting protein for CMA - outside of the 
      tetrapod clade, led to the paradigm that this cellular function was (presumably) 
      restricted to mammals and birds. However, after we identified expressed sequences 
      displaying high sequence homology with the mammalian LAMP2A in several fish 
      species, our findings challenge that view and suggest that CMA likely appeared 
      much earlier during evolution than initially thought. Hence, our results do not 
      only shed an entirely new light on the evolution of CMA, but also bring new 
      perspectives on the possible use of complementary genetic models, such as 
      zebrafish or medaka for studying CMA function from a comparative angle/view.
FAU - Lescat, Laury
AU  - Lescat L
AD  - a UMR1419 Nutrition Metabolisme Aquaculture , INRA-UPPA , St-Pee-sur-Nivelle , 
      France.
FAU - Herpin, Amaury
AU  - Herpin A
AUID- ORCID: 0000-0002-0630-4027
AD  - b INRA, UR1037 Fish Physiology and Genomics , Rennes , France.
FAU - Mourot, Brigitte
AU  - Mourot B
AD  - b INRA, UR1037 Fish Physiology and Genomics , Rennes , France.
FAU - Veron, Vincent
AU  - Veron V
AD  - a UMR1419 Nutrition Metabolisme Aquaculture , INRA-UPPA , St-Pee-sur-Nivelle , 
      France.
FAU - Guiguen, Yann
AU  - Guiguen Y
AUID- ORCID: 0000-0001-5464-6219
AD  - b INRA, UR1037 Fish Physiology and Genomics , Rennes , France.
FAU - Bobe, Julien
AU  - Bobe J
AUID- ORCID: 0000-0002-9355-8227
AD  - b INRA, UR1037 Fish Physiology and Genomics , Rennes , France.
FAU - Seiliez, Iban
AU  - Seiliez I
AUID- ORCID: 0000-0002-2202-1756
AD  - a UMR1419 Nutrition Metabolisme Aquaculture , INRA-UPPA , St-Pee-sur-Nivelle , 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180720
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (Molecular Chaperones)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - *Autophagy
MH  - Birds/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Mammals/genetics/*metabolism
MH  - Molecular Chaperones/chemistry/genetics/*metabolism
MH  - RNA, Messenger/genetics/metabolism
PMC - PMC6103740
OTO - NOTNLM
OT  - Chaperone-mediated autophagy
OT  - LAMP2A
OT  - RNA-seq
OT  - evolution
OT  - fish
EDAT- 2018/06/23 06:00
MHDA- 2019/10/11 06:00
PMCR- 2019/07/20
CRDT- 2018/06/23 06:00
PHST- 2018/06/23 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
PHST- 2018/06/23 06:00 [entrez]
PHST- 2019/07/20 00:00 [pmc-release]
AID - 1460021 [pii]
AID - 10.1080/15548627.2018.1460021 [doi]
PST - ppublish
SO  - Autophagy. 2018;14(7):1267-1270. doi: 10.1080/15548627.2018.1460021. Epub 2018 
      Jul 20.