PMID- 29929449
OWN - NLM
STAT- MEDLINE
DCOM- 20190628
LR  - 20240214
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 14
IP  - 7
DP  - 2018
TI  - Aspirin-another caloric-restriction mimetic.
PG  - 1162-1163
LID - 10.1080/15548627.2018.1454810 [doi]
AB  - The capacity of cells and organisms to sustain, and to eventually adapt to, 
      environmental and genetic insults declines with age. Because 
      macroautophagy/autophagy is regarded as one of the major determinants of cellular 
      fitness in vitro and in vivo, maneuvers that aim at promoting autophagy may slow 
      down aging and promote health span. Caloric restriction (CR), a reduction in 
      caloric intake without malnutrition, efficiently counteracts aging-associated 
      features, yet is difficult to be applied to humans. Caloric-restriction mimetics 
      (CRMs) are pharmacological agents that recapitulate the main biochemical 
      properties of CR, namely a global reduction of protein acetylation and the 
      induction of autophagy. We found that the ancient drug aspirin and its active 
      metabolite salicylate stimulate autophagic flux by virtue of their inhibitory 
      action on acetyltransferase EP300. The inhibition of EP300 results from a direct 
      competition between salicylate and acetyl coenzyme A for binding to the catalytic 
      domain of the enzyme. This mode of action appears to be conserved across 
      evolution as it accounts for the induction of autophagy by aspirin in various 
      mouse models and in the nematode Caenorhabditis elegans. In sum, aspirin acts as 
      a CRM.
FAU - Pietrocola, Federico
AU  - Pietrocola F
AD  - a Gustave Roussy Cancer Campus , Villejuif , France.
AD  - b INSERM, U1138 , Paris , France.
AD  - c Equipe 11 labellisee par la Ligue Nationale contre le Cancer , Centre de 
      Recherche des Cordeliers , Paris , France.
AD  - d Universite Paris Descartes/Paris V, Sorbonne Paris Cite , Paris , France.
AD  - e Universite Pierre & Marie Curie , Paris , France.
FAU - Castoldi, Francesca
AU  - Castoldi F
AD  - a Gustave Roussy Cancer Campus , Villejuif , France.
AD  - b INSERM, U1138 , Paris , France.
AD  - c Equipe 11 labellisee par la Ligue Nationale contre le Cancer , Centre de 
      Recherche des Cordeliers , Paris , France.
AD  - d Universite Paris Descartes/Paris V, Sorbonne Paris Cite , Paris , France.
AD  - e Universite Pierre & Marie Curie , Paris , France.
AD  - f Faculte de Medecine , Universite Paris-Sud/Paris XI , Kremlin-Bicetre , France.
AD  - g Sotio a.c ., Prague , Czech Republic.
FAU - Maiuri, Maria Chiara
AU  - Maiuri MC
AD  - a Gustave Roussy Cancer Campus , Villejuif , France.
AD  - b INSERM, U1138 , Paris , France.
AD  - c Equipe 11 labellisee par la Ligue Nationale contre le Cancer , Centre de 
      Recherche des Cordeliers , Paris , France.
AD  - d Universite Paris Descartes/Paris V, Sorbonne Paris Cite , Paris , France.
AD  - e Universite Pierre & Marie Curie , Paris , France.
FAU - Kroemer, Guido
AU  - Kroemer G
AUID- ORCID: 0000-0002-9334-4405
AD  - a Gustave Roussy Cancer Campus , Villejuif , France.
AD  - b INSERM, U1138 , Paris , France.
AD  - c Equipe 11 labellisee par la Ligue Nationale contre le Cancer , Centre de 
      Recherche des Cordeliers , Paris , France.
AD  - d Universite Paris Descartes/Paris V, Sorbonne Paris Cite , Paris , France.
AD  - e Universite Pierre & Marie Curie , Paris , France.
AD  - f Faculte de Medecine , Universite Paris-Sud/Paris XI , Kremlin-Bicetre , France.
AD  - h Metabolomics and Cell Biology Platforms , Gustave Roussy Cancer Campus , 
      Villejuif , France.
AD  - i Pole de Biologie , Hopital Europeen Georges Pompidou, AP-HP, Karolinska 
      Institute , Paris , France.
AD  - j Department of Women's and Children's Health , Karolinska University Hospital , 
      Stockholm , Sweden.
LA  - eng
GR  - P 27893/FWF_/Austrian Science Fund FWF/Austria
GR  - P 29262/FWF_/Austrian Science Fund FWF/Austria
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180718
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 72-89-9 (Acetyl Coenzyme A)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
CON - Cell Rep. 2018 Feb 27;22(9):2395-2407. PMID: 29490275
MH  - Acetyl Coenzyme A
MH  - Animals
MH  - Aspirin
MH  - *Autophagy
MH  - Caenorhabditis elegans
MH  - *Caloric Restriction
MH  - Humans
MH  - Mice
PMC - PMC6103658
OTO - NOTNLM
OT  - AMPK
OT  - Acetylation
OT  - aging
OT  - autophagy
OT  - fasting
OT  - inflammation
OT  - longevity
OT  - mitophagy
OT  - salicylate
EDAT- 2018/06/23 06:00
MHDA- 2019/06/30 06:00
PMCR- 2019/07/18
CRDT- 2018/06/23 06:00
PHST- 2018/06/23 06:00 [pubmed]
PHST- 2019/06/30 06:00 [medline]
PHST- 2018/06/23 06:00 [entrez]
PHST- 2019/07/18 00:00 [pmc-release]
AID - 1454810 [pii]
AID - 10.1080/15548627.2018.1454810 [doi]
PST - ppublish
SO  - Autophagy. 2018;14(7):1162-1163. doi: 10.1080/15548627.2018.1454810. Epub 2018 
      Jul 18.