PMID- 29930690
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1743-7075 (Print)
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 15
DP  - 2018
TI  - The effects of alpha-lipoic acid supplementation on inflammatory markers among 
      patients with metabolic syndrome and related disorders: a systematic review and 
      meta-analysis of randomized controlled trials.
PG  - 39
LID - 10.1186/s12986-018-0274-y [doi]
LID - 39
AB  - OBJECTIVE: This systematic review and meta-analysis of randomized controlled 
      trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) 
      supplementation on the inflammatory markers among patients with metabolic 
      syndrome (MetS) and related disorders. METHODS: We searched the following 
      databases until November 2017: PubMed, MEDLINE, EMBASE, Web of Science, and 
      Cochrane Central Register of Controlled Trials. Three reviewers independently 
      assessed study eligibility, extracted data, and evaluated risk of bias of 
      included primary studies. Statistical heterogeneity was assessed using Cochran's 
      Q test and I-square (I(2)) statistic. Data were pooled by using the random-effect 
      model and standardized mean difference (SMD) was considered as the summary effect 
      size. RESULTS: Eighteen trials out of 912 potential citations were found to be 
      eligible for our meta-analysis. The findings indicated that ALA supplementation 
      significantly decreased C-reactive protein (CRP) (SMD = - 1.52; 95% CI, - 2.25, 
      - 0.80; P < 0.001), interlokin-6 (IL-6) (SMD = - 1.96; 95% CI, - 2.60, - 1.32; 
      P < 0.001), and tumor necrosis factor alpha levels (TNF-alpha) (SMD = - 2.62; 95% CI, 
      - 3.70, - 1.55; P < 0.001) in patients diagnosed with metabolic diseases. 
      CONCLUSION: In summary, the current meta-analysis demonstrated the promising 
      impact of ALA administration on decreasing inflammatory markers such as CRP, IL-6 
      and TNF-alpha among patients with MetS and related disorders.
FAU - Akbari, Maryam
AU  - Akbari M
AD  - 1Health Policy Research Center, Institute of Health, Student Research Committee, 
      Shiraz University of Medical Sciences, Shiraz, Iran. ISNI: 0000 0000 8819 4698. 
      GRID: grid.412571.4
FAU - Ostadmohammadi, Vahidreza
AU  - Ostadmohammadi V
AD  - 2Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan 
      University of Medical Sciences, Kashan, I.R Iran. ISNI: 0000 0004 0612 1049. 
      GRID: grid.444768.d
FAU - Tabrizi, Reza
AU  - Tabrizi R
AD  - 1Health Policy Research Center, Institute of Health, Student Research Committee, 
      Shiraz University of Medical Sciences, Shiraz, Iran. ISNI: 0000 0000 8819 4698. 
      GRID: grid.412571.4
FAU - Mobini, Moein
AU  - Mobini M
AD  - 3Kinesiology Department, University of Calgary, Calgary, AB Canada. ISNI: 0000 
      0004 1936 7697. GRID: grid.22072.35
FAU - Lankarani, Kamran B
AU  - Lankarani KB
AD  - 4Health Policy Research Center, Institute of Health, Shiraz University of Medical 
      Sciences, Shiraz, Iran. ISNI: 0000 0000 8819 4698. GRID: grid.412571.4
FAU - Moosazadeh, Mahmood
AU  - Moosazadeh M
AD  - 5Health Science Research Center, Addiction Institute, Mazandaran University of 
      Medical Sciences, Sari, Iran. ISNI: 0000 0001 2227 0923. GRID: grid.411623.3
FAU - Heydari, Seyed Taghi
AU  - Heydari ST
AD  - 4Health Policy Research Center, Institute of Health, Shiraz University of Medical 
      Sciences, Shiraz, Iran. ISNI: 0000 0000 8819 4698. GRID: grid.412571.4
FAU - Chamani, Maryam
AU  - Chamani M
AD  - 6Department of Gynecology and Obstetrics, School of Medicine, Iran University of 
      Medical Sciences, Tehran, Iran. GRID: grid.411746.1
FAU - Kolahdooz, Fariba
AU  - Kolahdooz F
AD  - 7Indigenous and Global Health Research, Department of Medicine, University of 
      Alberta, Edmonton, Canada. GRID: grid.17089.37
FAU - Asemi, Zatollah
AU  - Asemi Z
AUID- ORCID: 0000-0001-5265-4792
AD  - 2Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan 
      University of Medical Sciences, Kashan, I.R Iran. ISNI: 0000 0004 0612 1049. 
      GRID: grid.444768.d
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180605
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC5989440
OTO - NOTNLM
OT  - Alpha-lipoic acid
OT  - Inflammatory markers
OT  - Meta-analysis
COIS- All procedures performed in studies involving human participants were in 
      accordance with the ethical standards of the institutional and national research 
      committee and with the 1964 Helsinki declaration and its later amendments.The 
      authors declare that they have no competing interests.Springer Nature remains 
      neutral with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2018/06/23 06:00
MHDA- 2018/06/23 06:01
PMCR- 2018/06/05
CRDT- 2018/06/23 06:00
PHST- 2018/03/09 00:00 [received]
PHST- 2018/05/01 00:00 [accepted]
PHST- 2018/06/23 06:00 [entrez]
PHST- 2018/06/23 06:00 [pubmed]
PHST- 2018/06/23 06:01 [medline]
PHST- 2018/06/05 00:00 [pmc-release]
AID - 274 [pii]
AID - 10.1186/s12986-018-0274-y [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2018 Jun 5;15:39. doi: 10.1186/s12986-018-0274-y. eCollection 
      2018.