PMID- 29931907
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 33
IP  - 6
DP  - 2017 Jun 8
TI  - [Therapeutic effects of Chai Qin Cheng Qi decoction on severe acute pancreatitis 
      complicated liver damage in rats and its mechanisms].
PG  - 550-554
LID - 10.12047/j.cjap.5601.2017.130 [doi]
AB  - OBJECTIVE: To study the effects of Chai Qin Cheng Qi Decoction(CQCQD)(Traditional 
      Chinese Medicine)on severe acute pancreatitis (SAP)complicated liver damage in 
      rats. METHODS: Seventy-two SD rats were randomly divided into three 
      groups(n=24):Sham group, SAP group and CQCQD treatment group. SAP model was 
      induced by retrograde injection with sodium taurocholate. The rats in CQCQD group 
      received treatment with CQCQD. After modeling 1 h, 5 h, 10 h, pancreas and liver 
      histopathological changes were observed. The serum levels of interleukin-6(IL-6), 
      amylase(AMS), alanine aminotransferase(ALT) and aspartate transaminase(AST) were 
      detected. IL-6 and monocyte chemotactic protein 1(MCP-1)mRNA in pancreas and 
      liver were assayed. RESULTS: Compared with sham group, the activities of AMS,ALT 
      and AST and the serum level of IL-6 in SAP group were increased significantly. 
      The levels of MCP-1 and IL-6 mRNA in pancreas and liver tissue were increased 
      (P<0.05). Compared with SAP group, the activities of AMS,ALT and AST and the 
      level of IL-6 in CQCQD group were reduced significantly (P<0.05). The pancreas 
      and liver tissue pathological damage alleviated. The levels of IL-6 and MCP-1mRNA 
      in pancreas and liver were decreased significantly(P<0.05). CONCLUSIONS: MCP-1 
      takes part in the progression of SAP complicated liver damage; CQCQD can 
      significantly inhibit the expression of pancreas and liver MCP-1, alleviate 
      pathological damage of pancreas and liver in SAP and play a therapeutic role in 
      SAP complicated liver damage.
FAU - Dang, Lin
AU  - Dang L
AD  - School of Basic Medicine, Shanxi University of Traditional Chinese Medicine, 
      Xianyang 712046, China.
FAU - Zhang, Xiao-Qin
AU  - Zhang XQ
AD  - School of Basic Medicine, Shanxi University of Traditional Chinese Medicine, 
      Xianyang 712046, China.
FAU - Liu, Fang
AU  - Liu F
AD  - School of Basic Medicine, Shanxi University of Traditional Chinese Medicine, 
      Xianyang 712046, China.
FAU - Xu, Xiao-Fan
AU  - Xu XF
AD  - Experimental Center of Medical Science and Research, Shanxi University of 
      Traditional Chinese Medicine, Xianyang 712046, China.
FAU - Li, Fang-Fang
AU  - Li FF
AD  - Experimental Center of Medical Science and Research, Shanxi University of 
      Traditional Chinese Medicine, Xianyang 712046, China.
FAU - Wei, Xu
AU  - Wei X
AD  - School of Basic Medicine, Shanxi University of Traditional Chinese Medicine, 
      Xianyang 712046, China.
FAU - Zhang, Hong
AU  - Zhang H
AD  - Experimental Center of Medical Science and Research, Shanxi University of 
      Traditional Chinese Medicine, Xianyang 712046, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chai Qin Cheng Qi decoction)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Il6 protein, rat)
RN  - 0 (Interleukin-6)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - EC 3.2.1.- (Amylases)
SB  - IM
MH  - Acute Disease
MH  - Alanine Transaminase/blood
MH  - Amylases/blood
MH  - Animals
MH  - Aspartate Aminotransferases/blood
MH  - Chemokine CCL2/metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Interleukin-6/blood
MH  - Liver/*drug effects/pathology
MH  - Liver Diseases/*drug therapy/etiology
MH  - Pancreatitis/complications/*drug therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Chai Qin Cheng Qi Decoction (CQCQD)
OT  - MCP-1
OT  - liver damage
OT  - rat
OT  - severe acute pancreatitis (SAP)
EDAT- 2018/06/23 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/06/23 06:00
PHST- 2018/06/23 06:00 [entrez]
PHST- 2018/06/23 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
AID - 10.12047/j.cjap.5601.2017.130 [doi]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2017 Jun 8;33(6):550-554. doi: 
      10.12047/j.cjap.5601.2017.130.