PMID- 29932126
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231115
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 8
IP  - 7
DP  - 2018 Jun 22
TI  - High and Low Levels of an NTRK2-Driven Genetic Profile Affect Motor- and 
      Cognition-Associated Frontal Gray Matter in Prodromal Huntington's Disease.
LID - 10.3390/brainsci8070116 [doi]
LID - 116
AB  - This study assessed how BDNF (brain-derived neurotrophic factor) and other genes 
      involved in its signaling influence brain structure and clinical functioning in 
      pre-diagnosis Huntington's disease (HD). Parallel independent component analysis 
      (pICA), a multivariate method for identifying correlated patterns in multimodal 
      datasets, was applied to gray matter concentration (GMC) and genomic data from a 
      sizeable PREDICT-HD prodromal cohort (N = 715). pICA identified a genetic 
      component highlighting NTRK2, which encodes BDNF's TrkB receptor, that correlated 
      with a GMC component including supplementary motor, precentral/premotor cortex, 
      and other frontal areas (p < 0.001); this association appeared to be driven by 
      participants with high or low levels of the genetic profile. The frontal GMC 
      profile correlated with cognitive and motor variables (Trail Making Test A (p = 
      0.03); Stroop Color (p = 0.017); Stroop Interference (p = 0.04); Symbol Digit 
      Modalities Test (p = 0.031); Total Motor Score (p = 0.01)). A top-weighted NTRK2 
      variant (rs2277193) was protectively associated with Trail Making Test B (p = 
      0.007); greater minor allele numbers were linked to a better performance. These 
      results support the idea of a protective role of NTRK2 in prodromal HD, 
      particularly in individuals with certain genotypes, and suggest that this gene 
      may influence the preservation of frontal gray matter that is important for 
      clinical functioning.
FAU - Ciarochi, Jennifer A
AU  - Ciarochi JA
AUID- ORCID: 0000-0002-6312-7901
AD  - Neuroscience Institute, Georgia State University, Atlanta, GA 30302, USA. 
      jciarochi1@student.gsu.edu.
FAU - Liu, Jingyu
AU  - Liu J
AD  - The Mind Research Network, Albuquerque, NM 87106, USA. jliu@mrn.org.
FAU - Calhoun, Vince
AU  - Calhoun V
AD  - The Mind Research Network, Albuquerque, NM 87106, USA. vcalhoun@mrn.org.
AD  - Department of Electrical and Computer Engineering, University of New Mexico, 
      Albuquerque, NM 87131, USA. vcalhoun@mrn.org.
FAU - Johnson, Hans
AU  - Johnson H
AUID- ORCID: 0000-0001-9513-2660
AD  - Iowa Mental Health Clinical Research Center, Department of Psychiatry, University 
      of Iowa, Iowa City, IA 52242, USA. hans-johnson@uiowa.edu.
FAU - Misiura, Maria
AU  - Misiura M
AD  - Department of Psychology, Georgia State University, Atlanta, GA 30302, USA. 
      mmisiura1@student.gsu.edu.
FAU - Bockholt, H Jeremy
AU  - Bockholt HJ
AD  - The Mind Research Network, Albuquerque, NM 87106, USA. jbockholt@mrn.org.
FAU - Espinoza, Flor A
AU  - Espinoza FA
AD  - The Mind Research Network, Albuquerque, NM 87106, USA. fespinoza@mrn.org.
FAU - Caprihan, Arvind
AU  - Caprihan A
AD  - The Mind Research Network, Albuquerque, NM 87106, USA. acaprihan@mrn.org.
FAU - Plis, Sergey
AU  - Plis S
AD  - The Mind Research Network, Albuquerque, NM 87106, USA. splis@mrn.org.
FAU - Turner, Jessica A
AU  - Turner JA
AD  - Neuroscience Institute, Georgia State University, Atlanta, GA 30302, USA. 
      jturner63@gsu.edu.
AD  - Department of Psychology, Georgia State University, Atlanta, GA 30302, USA. 
      jturner63@gsu.edu.
FAU - Paulsen, Jane S
AU  - Paulsen JS
AUID- ORCID: 0000-0002-0983-228X
AD  - Iowa Mental Health Clinical Research Center, Department of Psychiatry, University 
      of Iowa, Iowa City, IA 52242, USA. jane-paulsen@uiowa.edu.
AD  - Department of Neurology, University of Iowa, Iowa City, IA 52242, USA. 
      jane-paulsen@uiowa.edu.
AD  - Department of Psychology, University of Iowa, Iowa City, IA 52242, USA. 
      jane-paulsen@uiowa.edu.
CN  - PREDICT-HD Investigators and Coordinators of the Huntington Study Group
LA  - eng
GR  - MR/L010305/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20180622
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC6071032
OTO - NOTNLM
OT  - Huntington's disease
OT  - brain-derived neurotrophic factor
OT  - independent component analysis
OT  - supplementary motor
OT  - tropomyosin receptor kinase B
COIS- The authors declare no conflict of interest. The founding sponsors had no role in 
      the design of the study; in the collection, analyses, or interpretation of data; 
      in the writing of the manuscript, and in the decision to publish the results.
EDAT- 2018/06/23 06:00
MHDA- 2018/06/23 06:01
PMCR- 2018/07/01
CRDT- 2018/06/23 06:00
PHST- 2018/05/16 00:00 [received]
PHST- 2018/06/12 00:00 [revised]
PHST- 2018/06/20 00:00 [accepted]
PHST- 2018/06/23 06:00 [entrez]
PHST- 2018/06/23 06:00 [pubmed]
PHST- 2018/06/23 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - brainsci8070116 [pii]
AID - brainsci-08-00116 [pii]
AID - 10.3390/brainsci8070116 [doi]
PST - epublish
SO  - Brain Sci. 2018 Jun 22;8(7):116. doi: 10.3390/brainsci8070116.