PMID- 29933036 OWN - NLM STAT- MEDLINE DCOM- 20190726 LR - 20190726 IS - 1873-2747 (Electronic) IS - 0361-9230 (Linking) VI - 142 DP - 2018 Sep TI - Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats. PG - 1-7 LID - S0361-9230(18)30165-5 [pii] LID - 10.1016/j.brainresbull.2018.06.007 [doi] AB - Vortioxetine is a novel antidepressant capable of improving depressive and cognitive symptoms associated with major depressive disorder (MDD). This study established whether treatment with vortioxetine, fluoxetine or vehicle alters the modulation of brain-derived neurotrophic factor (BDNF) under the 21-day chronic unpredictable mild stress (CUMS) condition in 54 Sprague-Dawley rats. Vortioxetine mitigated the reduction in rearing behavior by CUMS in the OFT on day 7 and 21, as well as sucrose preference on day 21. Histological examination by H&E staining showed that most hippocampal neurons in the CUMS + FLU and CUMS + VOR groups were intact, although some of them demonstrated karyopyknosis. The mean optical density value of hippocampal BDNF was significantly higher in the CUMS + VOR group than the CUMS and CUMS + FLU groups. There was a trend towards a higher number of hippocampal BDNF-positive cells in the CUMS + VOR group, although it did not reach statistical significance. In conclusion, vortioxetine, but not fluoxetine, increased hippocampal BDNF levels in rats subject to CUMS. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Lu, Yanxia AU - Lu Y AD - Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China. Electronic address: A0068932@u.nus.edu. FAU - Ho, Cyrus S AU - Ho CS AD - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Psychological Medicine, National University Health System, Singapore. FAU - McIntyre, Roger S AU - McIntyre RS AD - Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Department of Toxicology and Pharmacology, University of Toronto, Toronto, ON, Canada. FAU - Wang, Wei AU - Wang W AD - Department of Clinical Psychology and Psychiatry, School of Public Health, Zhejiang University College of Medicine, Hangzhou, China. Electronic address: drwangwei@zju.edu.cn. FAU - Ho, Roger C AU - Ho RC AD - Department of Psychological Medicine, National University Health System, Singapore; Biomedical Institute for Global Health Research and Technology (BIGHEART), National University of Singapore. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180619 PL - United States TA - Brain Res Bull JT - Brain research bulletin JID - 7605818 RN - 0 (Antidepressive Agents) RN - 0 (Bdnf protein, rat) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 01K63SUP8D (Fluoxetine) RN - 3O2K1S3WQV (Vortioxetine) MH - Anhedonia/drug effects/physiology MH - Animals MH - Antidepressive Agents/*pharmacology MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Depressive Disorder, Major/*drug therapy/metabolism/pathology MH - Disease Models, Animal MH - Fluoxetine/*pharmacology MH - Hippocampus/*drug effects/metabolism MH - Male MH - Neurons/drug effects/metabolism/pathology MH - Random Allocation MH - Rats, Sprague-Dawley MH - Stress, Psychological/drug therapy/metabolism/pathology MH - Vortioxetine/*pharmacology OTO - NOTNLM OT - Brain-derived neurotrophic factors OT - Chronic unpredictable mild stress OT - Depression OT - Fluoxetine OT - Vortioxetine EDAT- 2018/06/23 06:00 MHDA- 2019/07/28 06:00 CRDT- 2018/06/23 06:00 PHST- 2018/03/09 00:00 [received] PHST- 2018/06/01 00:00 [revised] PHST- 2018/06/14 00:00 [accepted] PHST- 2018/06/23 06:00 [pubmed] PHST- 2019/07/28 06:00 [medline] PHST- 2018/06/23 06:00 [entrez] AID - S0361-9230(18)30165-5 [pii] AID - 10.1016/j.brainresbull.2018.06.007 [doi] PST - ppublish SO - Brain Res Bull. 2018 Sep;142:1-7. doi: 10.1016/j.brainresbull.2018.06.007. Epub 2018 Jun 19.