PMID- 29933243
OWN - NLM
STAT- MEDLINE
DCOM- 20181023
LR  - 20181023
IS  - 2191-0286 (Electronic)
IS  - 0792-6855 (Linking)
VI  - 29
IP  - 4
DP  - 2018 Jul 26
TI  - Antioxidant-mediated neuroprotection by Allium schoenoprasum L. leaf extract 
      against ischemia reperfusion-induced cerebral injury in mice.
PG  - 403-410
LID - 10.1515/jbcpp-2017-0070 [doi]
AB  - Background Oxidative stress is strongly implicated in ischemia reperfusion 
      (IR)-mediated functional and neuronal impairment. Therefore, strategies employing 
      antioxidants to reverse the damage due to IR are being investigated. Allium 
      schoenoprasum L. is a culinary medicine whose antioxidant properties are well 
      documented but whose neuroprotective potential has not been examined. Hence, the 
      present study was designed to evaluate the effect of A. schoenoprasum leaf 
      extract (ASLE) on functional deficit against IR-induced cerebral injury in mice. 
      Methods Acute toxicity studies of ASLE were performed following the Organisation 
      for Economic Co-operation and Development Guideline 423. IR injury was induced by 
      bilateral common carotid artery occlusion (BCCAO) for 15 min followed by 24-h 
      reperfusion. Animals were treated for 7 days with ASLE (200 and 400 mg/kg, p.o. 
      once daily) after IR injury. Functional outcomes (memory and sensorimotor 
      functions) were measured using Morris water maze and neurological severity score, 
      respectively. Cerebral infarct size and oxidative stress (thiobarbituric acid 
      reactive species (TBARS), reduced glutathione (GSH), and superoxide dismutase 
      (SOD) activity) were measured in order to elucidate the neuroprotective mechanism 
      of ASLE. Results No toxic effects of ASLE were observed in mice. Oral treatment 
      with ASLE for 7 days significantly attenuated IR-mediated memory and sensorimotor 
      function deficit in the animals. The extract also reduced the cerebral infarct 
      size and rise in brain TBARS levels, and restored the GSH levels and SOD 
      activity. Conclusions The results of the present study suggest that ASLE is safe 
      and effective in improving functional outcomes. It demonstrates neuroprotective 
      effect by enhancing the antioxidant defence against IR injury.
FAU - Singh, Varinder
AU  - Singh V
AD  - Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 
      Patiala, Punjab, India.
FAU - Krishan, Pawan
AU  - Krishan P
AD  - Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 
      Patiala, Punjab, India.
FAU - Shri, Richa
AU  - Shri R
AD  - Department of Pharmaceutical Sciences and Drug Research, Punjabi University, 
      Patiala, Punjab, 147002, India.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Basic Clin Physiol Pharmacol
JT  - Journal of basic and clinical physiology and pharmacology
JID - 9101750
RN  - 0 (Antioxidants)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Brain/drug effects/metabolism
MH  - Cerebral Infarction/*drug therapy/metabolism
MH  - Chive/*chemistry
MH  - Glutathione/metabolism
MH  - Memory/drug effects
MH  - Mice
MH  - Neuroprotection/*drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Phytotherapy/methods
MH  - Plant Extracts/*pharmacology
MH  - Reperfusion Injury/*drug therapy/metabolism
OTO - NOTNLM
OT  - Allium schoenoprasum L.
OT  - antioxidant
OT  - ischemia reperfusion
OT  - memory
OT  - neuroprotection
OT  - sensorimotor function
EDAT- 2018/06/23 06:00
MHDA- 2018/10/24 06:00
CRDT- 2018/06/23 06:00
PHST- 2017/05/08 00:00 [received]
PHST- 2017/12/02 00:00 [accepted]
PHST- 2018/06/23 06:00 [pubmed]
PHST- 2018/10/24 06:00 [medline]
PHST- 2018/06/23 06:00 [entrez]
AID - /j/jbcpp.ahead-of-print/jbcpp-2017-0070/jbcpp-2017-0070.xml [pii]
AID - 10.1515/jbcpp-2017-0070 [doi]
PST - ppublish
SO  - J Basic Clin Physiol Pharmacol. 2018 Jul 26;29(4):403-410. doi: 
      10.1515/jbcpp-2017-0070.