PMID- 29936998
OWN - NLM
STAT- MEDLINE
DCOM- 20190416
LR  - 20190416
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 229
DP  - 2018 Sep
TI  - Effects of different foods on blood glucose and lipid in type 2 diabetes mellitus 
      in a rat model.
PG  - 254-261
LID - S0022-4804(18)30128-8 [pii]
LID - 10.1016/j.jss.2018.02.045 [doi]
AB  - BACKGROUND: This study investigated the effects of duodenal-jejunal bypass (DJB) 
      and new biliopancreatic diversion (NBPD) on blood glucose and lipid levels in 
      type 2 diabetes mellitus (T2DM). An additional goal was to explore the potential 
      mechanism or mechanisms underlying the therapeutic effects of surgery on T2DM. 
      METHODS: Rats were fed a high-fat, high-glucose diet and then were 
      intraperitoneally injected with streptozotocin, 35 mg/kg, to induce T2DM. Then, 
      33 T2DM rats were randomly assigned to one of three groups, a DJB group, an NBPD 
      group, or a sham group. Fasting body weight, fasting glucose, and 2-h 
      postprandial glucose were measured before and after surgery. Then, the rats were 
      intragastrically administered lipid emulsion, peanut oil, glucose, starch, and 
      Ansul, and blood glucose and lipid levels were measured. RESULTS: One week after 
      surgery, 2-h postprandial glucose decreased from 24.41 +/- 2.28 mmol/L before 
      surgery to 19.87 +/- 4.07 mmol/L after surgery in the DJB group, and from 
      25.88 +/- 1.91 mmol/L before surgery to 20.34 +/- 5.76 mmol/L after surgery in the 
      NBPD group. After intragastric administration of lipid emulsion, free fatty acid 
      levels increased from 534.60 +/- 70.99 to 1082.83 +/- 259.67 muEq/L in the DJB group 
      and from 648.33 +/- 139.26 to 1258.67 +/- 204.18 muEq/L in the NBPD group. After 
      surgery, free fatty acid levels in the DJB group and NBPD group were 
      significantly lower than those in the sham group. CONCLUSIONS: Postprandial blood 
      glucose and lipids decreased after DJB and NBPD, which may be ascribed to 
      postoperative changes in digestion and absorption.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of 
      Fujian Medical University, National Abdominal Surgery Institute of Fujian, Fuzhou 
      City, Fujian, PR China.
FAU - Yang, YaPeng
AU  - Yang Y
AD  - General Surgery Department, Luohe Central Hospital, Luohe, Henan, PR China.
FAU - Luo, BingLai
AU  - Luo B
AD  - Department of Gynecology, Longyan First Hospital, Longyan, Fujian, PR China.
FAU - Weng, ShanGeng
AU  - Weng S
AD  - Hepatopancreatobiliary Surgery Department, the First Affiliated Hospital of 
      Fujian Medical University, National Abdominal Surgery Institute of Fujian, Fuzhou 
      City, Fujian, PR China. Electronic address: shangeng@sina.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Anastomosis, Surgical
MH  - Animals
MH  - *Biliopancreatic Diversion
MH  - Blood Glucose/analysis/metabolism
MH  - Diabetes Mellitus, Experimental/blood/chemically induced/*surgery
MH  - Diabetes Mellitus, Type 2/blood/chemically induced/*surgery
MH  - Diet, High-Fat/adverse effects
MH  - Duodenum/*surgery
MH  - Gastrointestinal Absorption
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Jejunum/*surgery
MH  - Lipid Metabolism
MH  - Lipids/blood
MH  - Male
MH  - Postprandial Period
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Specific Pathogen-Free Organisms
MH  - Streptozocin/toxicity
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Blood glucose
OT  - Blood lipid
OT  - Duodenal-jejunal bypass
OT  - Modified biliopancreatic diversion
OT  - Type 2 diabetes mellitus
EDAT- 2018/06/26 06:00
MHDA- 2019/04/17 06:00
CRDT- 2018/06/26 06:00
PHST- 2017/07/16 00:00 [received]
PHST- 2018/02/16 00:00 [revised]
PHST- 2018/02/22 00:00 [accepted]
PHST- 2018/06/26 06:00 [entrez]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2019/04/17 06:00 [medline]
AID - S0022-4804(18)30128-8 [pii]
AID - 10.1016/j.jss.2018.02.045 [doi]
PST - ppublish
SO  - J Surg Res. 2018 Sep;229:254-261. doi: 10.1016/j.jss.2018.02.045.