PMID- 29937139
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20190930
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 32
IP  - 8
DP  - 2018 Aug
TI  - Role of plasma glucose level on myocardial perfusion in ST-segment elevation 
      myocardial infarction patients.
PG  - 764-769
LID - S1056-8727(17)31432-0 [pii]
LID - 10.1016/j.jdiacomp.2018.05.015 [doi]
AB  - AIMS: Hyperglycemia is frequent in patients with ST elevation myocardial 
      infarction (STEMI) and is associated with adverse outcome. Aim of our study was 
      to evaluate the correlation between admission plasma glucose level (PGL) and 
      coronary arteries flow velocity. METHODS: We enrolled 149 STEMI patients 
      successfully treated with primary percutaneous coronary intervention (pPCI). The 
      study population was divided into two groups based on PGL (< or >140 mg/dl) and 
      on history of diabetes, and the groups compared in terms of corrected TIMI frame 
      count (cTFC). RESULTS: Hyperglycemic patients had a significantly higher cTFC in 
      both the culprit (p < 0.0001) and non-culprit vessel (p: 0.0002); diabetes 
      history impairs as well cTFC of the culprit (p < 0.0001) and non-culprit vessel 
      (p: 0.0001). Within the subpopulation of diabetic patients hyperglycemic ones 
      showed higher cTFC in both the culprit (p 0.0013) and non-culprit vessel (p: 
      0.0006). Moreover in the whole population cTFC values of both arteries increase 
      linearly with the increment of admission PGL. CONCLUSIONS: Admission PGL affects 
      coronary flow of both culprit and non-culprit vessel. The impairment of coronary 
      flow is also demonstrated in known diabetic patients, suggesting to consider 
      hyperglycemia an additional risk factor. We finally demonstrated for the first 
      time a positive linear relationship between PGL and cTFC.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Pepe, Martino
AU  - Pepe M
AD  - Cardiovascular Diseases Section, Department of Emergency and Organ 
      Transplantation (DETO), University of Bari, Bari, Italy.
FAU - Zanna, Domenico
AU  - Zanna D
AD  - Cardiovascular Diseases Section, Department of Emergency and Organ 
      Transplantation (DETO), University of Bari, Bari, Italy.
FAU - Cafaro, Alessandro
AU  - Cafaro A
AD  - Department of Cardiology, General Hospital "F. Miulli", Acquaviva delle Fonti, 
      Bari, Italy.
FAU - Marchese, Alfredo
AU  - Marchese A
AD  - Department of Cardiology, Anthea Hospital, GVM Care & Research, Bari, Italy.
FAU - Addabbo, Francesco
AU  - Addabbo F
AD  - Department of Biomedical Sciences & Human Oncology, University of Bari Medical 
      School, Bari, Italy.
FAU - Navarese, Eliano Pio
AU  - Navarese EP
AD  - Department of Internal Medicine, Division of Cardiology, Pulmonology and Vascular 
      Medicine, Heinrich-Heine-University, Dusseldorf, Germany.
FAU - Napodano, Massimo
AU  - Napodano M
AD  - Department of Cardiac, Thoracic and Vascular Sciences, Hospital-University of 
      Padova, Padova, Italy.
FAU - Cecere, Annagrazia
AU  - Cecere A
AD  - Cardiovascular Diseases Section, Department of Emergency and Organ 
      Transplantation (DETO), University of Bari, Bari, Italy. Electronic address: 
      agcecere@gmail.com.
FAU - Resta, Fabrizio
AU  - Resta F
AD  - Department of Cardiology, "Santa Maria" Hospital, GVM Care & Research, Bari, 
      Italy.
FAU - Paradies, Valeria
AU  - Paradies V
AD  - Department of Cardiology, Maasstad Ziekenhuis Hospital, Rotterdam, Netherlands.
FAU - Bortone, Alessandro Santo
AU  - Bortone AS
AD  - Division of Heart Surgery, Department of Emergency and Organ Transplantation 
      (DETO), University of Bari, Bari, Italy.
FAU - Favale, Stefano
AU  - Favale S
AD  - Cardiovascular Diseases Section, Department of Emergency and Organ 
      Transplantation (DETO), University of Bari, Bari, Italy.
LA  - eng
PT  - Journal Article
DEP - 20180526
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Aged
MH  - Blood Flow Velocity
MH  - Blood Glucose/*physiology
MH  - Cohort Studies
MH  - Coronary Angiography
MH  - Coronary Circulation/*physiology
MH  - Coronary Vessels/diagnostic imaging/physiology
MH  - Female
MH  - Humans
MH  - Hyperglycemia/blood/complications/physiopathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Prognosis
MH  - ST Elevation Myocardial Infarction/*blood/*diagnosis/*physiopathology/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Hyperglycemia
OT  - Myocardial perfusion
OT  - Primary percutaneous coronary intervention
OT  - STEMI
OT  - TIMI frame count
EDAT- 2018/06/26 06:00
MHDA- 2019/10/01 06:00
CRDT- 2018/06/26 06:00
PHST- 2017/10/17 00:00 [received]
PHST- 2018/05/18 00:00 [revised]
PHST- 2018/05/19 00:00 [accepted]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2018/06/26 06:00 [entrez]
AID - S1056-8727(17)31432-0 [pii]
AID - 10.1016/j.jdiacomp.2018.05.015 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2018 Aug;32(8):764-769. doi: 
      10.1016/j.jdiacomp.2018.05.015. Epub 2018 May 26.