PMID- 29937720
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-5145 (Print)
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 12
DP  - 2018
TI  - Novel Insights Into the Mechanisms of Abdominal Pain in Obstructive Bowel 
      Disorders.
PG  - 23
LID - 10.3389/fnint.2018.00023 [doi]
LID - 23
AB  - Obstructive bowel disorders (OBD) are characterized by lumen distention due to 
      mechanical or functional obstruction in the gut. Abdominal pain is one of the 
      main symptoms in OBD. In this article, we aim to critically review the potential 
      mechanisms for acute and chronic pain in bowel obstruction (BO). While clustered 
      contractions and associated increase of intraluminal pressure may account for 
      colicky pain in simple obstruction, ischemia may be involved in acute pain in 
      severe conditions such as closed loop obstruction. Recent preclinical studies 
      discovered that visceral sensitivity is increased in BO, and visceral 
      hypersensitivity may underlie the mechanisms of chronic abdominal pain in BO. 
      Mounting evidence suggests that lumen distension, as a circumferential mechanical 
      stretch, alters gene expression (mechano-transcription) in the distended bowel, 
      and mechano-transcription of nociceptive and inflammatory mediators plays a 
      critical role in the development of visceral hypersensitivity in BO. 
      Mechano-transcription of nerve growth factor (NGF) in gut smooth muscle cells is 
      found to increase voltage-gated Na(+) channel (Na(v)) activity of the primary 
      sensory neurons by up-regulating expression of TTX-resistant Na(v)1.8, whereas 
      mechanical stretch-induced brain-derived neurotrophic factor (BDNF) reduces K(v) 
      currents especially A-type (IA) currents by down-regulating expression of 
      specific IA subtypes such as K(v)1.4. The NGF and BDNF mediated changes in gene 
      expression and channel functions in the primary sensory neurons may constitute 
      the main mechanisms of visceral hypersensitivity in OBD. In addition, mechanical 
      stretch-induced COX-2 and other inflammatory mediators in the gut may also 
      contribute to abdominal pain by activating and sensitizing nociceptors.
FAU - Shi, Xuan-Zheng
AU  - Shi XZ
AD  - Department of Internal Medicine, University of Texas Medical Branch, Galveston, 
      TX, United States.
FAU - Lin, You-Min
AU  - Lin YM
AD  - Department of Internal Medicine, University of Texas Medical Branch, Galveston, 
      TX, United States.
FAU - Hegde, Shrilakshmi
AU  - Hegde S
AD  - Department of Internal Medicine, University of Texas Medical Branch, Galveston, 
      TX, United States.
LA  - eng
GR  - R01 DK082563/DK/NIDDK NIH HHS/United States
GR  - R01 DK102811/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20180608
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC6002527
OTO - NOTNLM
OT  - abdominal pain
OT  - gene transcription
OT  - mechanical stretch
OT  - motility
OT  - sensory neurons
OT  - smooth muscle
OT  - visceral sensitivity
EDAT- 2018/06/26 06:00
MHDA- 2018/06/26 06:01
PMCR- 2018/01/01
CRDT- 2018/06/26 06:00
PHST- 2018/03/13 00:00 [received]
PHST- 2018/05/22 00:00 [accepted]
PHST- 2018/06/26 06:00 [entrez]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2018/06/26 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnint.2018.00023 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2018 Jun 8;12:23. doi: 10.3389/fnint.2018.00023. 
      eCollection 2018.