PMID- 29937835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2524-1753 (Electronic)
IS  - 1672-2930 (Print)
IS  - 1672-2930 (Linking)
VI  - 12
IP  - 1
DP  - 2017 Mar
TI  - Auditory deprivation modifies the expression of brain-derived neurotrophic factor 
      and tropomyosin receptor kinase B in the rat auditory cortex.
PG  - 34-40
LID - 10.1016/j.joto.2017.02.003 [doi]
AB  - The development and plasticity of central auditory system can be influenced by 
      the change of peripheral neuronal activity. However, the molecular mechanism 
      participating in the process remains elusive. Brain-derived neurotrophic factor 
      (BDNF) binding with its functional receptor tropomyosin receptor kinase B (TrkB) 
      has multiple effects on neurons. Here we used a rat model of auditory deprivation 
      by bilateral cochlear ablation, to investigate the changes in expression of BDNF 
      and TrkB in the auditory cortex after auditory deprivation that occurred during 
      the critical period for the development of central auditory system. Reverse 
      transcription-quantitative polymerase chain reaction (RT-qPCR) and 
      immunohistochemistry methods were adopted to detect the mRNA and protein 
      expression levels of BDNF and TrkB in the auditory cortex at 2, 4, 6 and 8 weeks 
      after surgery, respectively. The change in the expression of BDNF and TrkB mRNAs 
      and proteins followed similar trend. In the bilateral cochlear ablation groups, 
      the BDNF-TrkB expression level initially decreased at 2 weeks but increased at 4 
      weeks followed by the reduction at 6 and 8 weeks after cochlear removal, as 
      compared to the age-matched sham control groups. In conclusion, the BDNF-TrkB 
      signaling is involved in the plasticity of auditory cortex in an 
      activity-dependent manner.
FAU - Wang, Yuxing
AU  - Wang Y
AD  - Department of Otorhinolaryngology, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, Hebei, 050000, China.
FAU - Xu, Ou
AU  - Xu O
AD  - Department of Otorhinolaryngology, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, Hebei, 050000, China.
FAU - Liu, Yanxing
AU  - Liu Y
AD  - Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei, 
      050017, China.
FAU - Lu, Hong
AU  - Lu H
AD  - Department of Otorhinolaryngology, The Second Hospital of Hebei Medical 
      University, Shijiazhuang, Hebei, 050000, China.
LA  - eng
PT  - Journal Article
DEP - 20170308
PL  - China
TA  - J Otol
JT  - Journal of otology
JID - 101484080
PMC - PMC6011803
OTO - NOTNLM
OT  - Auditory cortex
OT  - Auditory deprivation
OT  - Brain-derived neurotrophic factor
OT  - Central plasticity
OT  - Tropomyosin receptor kinase B
EDAT- 2017/03/01 00:00
MHDA- 2017/03/01 00:01
PMCR- 2017/03/08
CRDT- 2018/06/26 06:00
PHST- 2016/11/10 00:00 [received]
PHST- 2017/02/16 00:00 [revised]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2018/06/26 06:00 [entrez]
PHST- 2017/03/01 00:00 [pubmed]
PHST- 2017/03/01 00:01 [medline]
PHST- 2017/03/08 00:00 [pmc-release]
AID - S1672-2930(16)30084-8 [pii]
AID - 10.1016/j.joto.2017.02.003 [doi]
PST - ppublish
SO  - J Otol. 2017 Mar;12(1):34-40. doi: 10.1016/j.joto.2017.02.003. Epub 2017 Mar 8.