PMID- 29938470
OWN - NLM
STAT- MEDLINE
DCOM- 20181025
LR  - 20230928
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Print)
IS  - 1513-7368 (Linking)
VI  - 19
IP  - 6
DP  - 2018 Jun 25
TI  - HPV Could be a Potential Factor of Survival in Laryngeal Cancer: a Preliminary 
      Study in Mexican Patients.
PG  - 1711-1716
AB  - Introduction: In Head and Neck (HN) cancer, the High-Risk Human Papillomavirus 
      (hr HPV) infection has been associated in about 40% of these tumors. The hr HPV 
      infection is one of the etiological factors of several epithelial tumors; 
      however, its association with the prognosis has not yet been established for 
      patients with Laryngeal Squamous Cell Carcinoma (LSCC). On the other hand, 
      Epidermal Growth Factor Receptor (EGFR) is a molecular marker widely studied in 
      cancer and its overexpression has been associated with poor prognosis in some 
      types of cancer, including the HN cancer. In the present study, we analyzed EGFR 
      expression and HPV detection in a cohort of Mexican patients with LSCC and define 
      their association with clinical-pathological and survival parameters. Methods: 
      EGFR expression analysis was performed by immunohistochemistry assay. A tissue 
      array was constructed based on 30 paraffin-embedded tissue samples. HPV detection 
      was performed by PCR. The results were then compared with the 
      clinical-pathological variables and outcome measures (Kaplan Meier and Cox 
      analysis). Results: High expression of EGFR was observed in 43% of the samples 
      and 20% of HPV detection. The statistical analyses provided evidence of 
      disassociation between clinical-pathological parameters and EGFR expression, but 
      there was an association with poor prognosis. Interestingly, HPV detection is 
      slightly associated with good prognosis. Conclusion: Both, EGFR overexpression 
      and HPV presence could be associated with an unfavorable prognosis in patients 
      with LSCC, independently of other clinical-pathological factors.
CI  - Creative Commons Attribution License
FAU - Peralta, Raul
AU  - Peralta R
AD  - Centro de Investigacion en Dinamica Celular, Universidad Autonoma del Estado de 
      Morelos, Cuernavaca , Mexico. Email: masava89@gmail.com
FAU - Garcia, Paola
AU  - Garcia P
FAU - Valdivia, Alejandra
AU  - Valdivia A
FAU - Lopez, Arianna
AU  - Lopez A
FAU - Apresa, Teresa
AU  - Apresa T
FAU - Hernandez, Dulce M
AU  - Hernandez DM
FAU - Gallegos, Francisco
AU  - Gallegos F
FAU - Alvarado-Cabrero, Isabel
AU  - Alvarado-Cabrero I
FAU - Vargas-De-Leon, Cruz
AU  - Vargas-De-Leon C
FAU - Davila, Sonia
AU  - Davila S
FAU - Romero, Pablo
AU  - Romero P
FAU - Salcedo, Mauricio
AU  - Salcedo M
LA  - eng
PT  - Journal Article
DEP - 20180625
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - 0 (DNA, Viral)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Carcinoma, Squamous Cell/*mortality/pathology/virology
MH  - DNA, Viral/genetics
MH  - ErbB Receptors/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/*mortality/pathology/virology
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Papillomaviridae/genetics/isolation & purification
MH  - Papillomavirus Infections/*mortality/pathology/virology
MH  - Prognosis
MH  - Survival Rate
PMC - PMC6103592
OTO - NOTNLM
OT  - *HPV
OT  - *EGFR
OT  - *prognosis
OT  - *laryngeal cancer
EDAT- 2018/06/26 06:00
MHDA- 2018/10/26 06:00
PMCR- 2018/03/01
CRDT- 2018/06/26 06:00
PHST- 2018/06/26 06:00 [entrez]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - APJCP-19-1711 [pii]
AID - 10.22034/APJCP.2018.19.6.1711 [doi]
PST - epublish
SO  - Asian Pac J Cancer Prev. 2018 Jun 25;19(6):1711-1716. doi: 
      10.22034/APJCP.2018.19.6.1711.