PMID- 29938910
OWN - NLM
STAT- MEDLINE
DCOM- 20190724
LR  - 20220409
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 13
IP  - 2
DP  - 2019 Apr
TI  - Interventions and social functioning in youth at risk of psychosis: A systematic 
      review and meta-analysis.
PG  - 169-180
LID - 10.1111/eip.12689 [doi]
AB  - AIM: Youth at clinical high risk (CHR) for psychosis often exhibit difficulties 
      in social functioning and poorer social functioning may be predictive of 
      transition to a psychotic disorder. Therefore, the primary objective of this 
      systematic review was to summarize the impact of all interventions on social 
      functioning in CHR samples. METHOD: Electronic databases PsycINFO, CINAHL, 
      Embase, EBM, and MEDLINE were searched from 1951 to June 2017. Studies were 
      selected if they included any intervention that reported changes in social 
      functioning in youth at CHR. Data were evaluated using random effects pairwise 
      meta-analyses, stratified by time, and reported as the standardized mean 
      difference (SMD). RESULTS: Nineteen studies met our inclusion criteria, including 
      a total of 1513 CHR participants. The mean age was 20.5 years and 47% were male. 
      Cognitive behavioural therapy (4 studies) did not significantly improve social 
      functioning at 6 months (SMD = 0.06; 95% confidence interval [CI] = -0.35, 0.46), 
      12 months (SMD = -0.15; 95% CI = -0.38, 0.08) and 18 months (SMD = 0.20; 95% 
      CI = -0.10, 0.50). Omega-3 (2 studies) did not significantly improve social 
      functioning at 6 months (SMD = 0.01; 95% CI = -0.21, 0.24) and 12 months 
      (SMD = -0.08; 95% CI = -0.33, 0.17). Lastly, cognitive remediation (3 studies) 
      did not significantly improve social functioning at 2- to 3-month follow-up 
      (SMD = 0.13, 95% CI = -0.18, 0.43). CONCLUSIONS: This systematic review and 
      meta-analysis demonstrated that no treatment significantly improved social 
      functioning in youth at CHR. Future randomized control trials are required that 
      are designed to target and improve social functioning in youth at CHR for 
      psychosis.
CI  - (c) 2018 John Wiley & Sons Australia, Ltd.
FAU - Devoe, Daniel J
AU  - Devoe DJ
AUID- ORCID: 0000-0003-4931-0205
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
FAU - Farris, Megan S
AU  - Farris MS
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
FAU - Townes, Parker
AU  - Townes P
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
FAU - Addington, Jean
AU  - Addington J
AUID- ORCID: 0000-0002-8298-0756
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Alberta, Canada.
LA  - eng
GR  - RO1MH105178/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20180625
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
MH  - Adolescent
MH  - Adult
MH  - Alberta
MH  - *Cognitive Behavioral Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Outcome and Process Assessment, Health Care
MH  - Psychotic Disorders/diagnosis/psychology/*therapy
MH  - Risk Assessment
MH  - *Social Adjustment
MH  - Social Behavior Disorders/diagnosis/psychology/*therapy
MH  - Young Adult
OTO - NOTNLM
OT  - *clinical high risk
OT  - *psychosis
OT  - *social functioning
OT  - *treatment
EDAT- 2018/06/26 06:00
MHDA- 2019/07/25 06:00
CRDT- 2018/06/26 06:00
PHST- 2018/01/17 00:00 [received]
PHST- 2018/03/28 00:00 [revised]
PHST- 2018/05/16 00:00 [accepted]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2018/06/26 06:00 [entrez]
AID - 10.1111/eip.12689 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2019 Apr;13(2):169-180. doi: 10.1111/eip.12689. Epub 
      2018 Jun 25.