PMID- 29940157
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20181127
IS  - 1096-0945 (Electronic)
IS  - 0014-4800 (Linking)
VI  - 105
IP  - 1
DP  - 2018 Aug
TI  - Correlation between PAI-1, leptin and ferritin with HOMA in HIV/AIDS patients.
PG  - 115-119
LID - S0014-4800(18)30157-6 [pii]
LID - 10.1016/j.yexmp.2018.06.004 [doi]
AB  - BACKGROUND: Data about correlation of interleukins (IL-1 alpha, IL-1 beta, IFN gamma, IL-2, 
      IL-4, IL-6, IL-8, IL-10), adipocytokines (leptin, adiponectin, monocyte 
      chemoattractant protein-1 (MCP-1), resistin, plasminogen activator inhibitor-1 
      (PAI-1), tumor necrosis factor alpha (TNFalpha), ferritin, C reactive protein (CRP) 
      and vascular endothelial growth factor (VEGF) with homeostasis model assessment 
      (HOMA) in HIV/AIDS patients are still limited. Therefore the aim of this study 
      was to evaluate the possible correlations of serum levels of PAI-1, leptin and 
      ferritin with HOMA in HIV/AIDS patients treated with combined antiretroviral 
      therapy (cART). METHODS: This cross-sectional study included 64 HIV/AIDS 
      patients, all Caucasians, receiving cART at the HIV/AIDS Centre, Belgrade, 
      Serbia. PAI-1, leptin, ferritin and insulin levels were measured using the 
      Metabolic Syndrome Array I (Randox Laboratories Ltd., London, UK), while 
      adiponectin and resistin levels were measured using Metabolic Syndrome Array II 
      (Randox Laboratories Ltd., London, UK), interleukins (IL-1 alpha, IL-1 beta, IFN gamma, 
      IL-2, IL-4, IL-6, IL-8, IL-10), MCP-1, TNF-alpha as well as VEGF was measured using 
      Cytokine Array I (Randox Laboratories Ltd., London, UK). Insulin resistance was 
      determined using the homeostasis model assessment index (HOMA). Multicollinearity 
      of independent variables in multivariate model was analyzed using Variance 
      Inflation Factor. RESULTS: Correlation analysis revealed significant correlations 
      between HOMA and waist circumference, body mass index, patients' age, number of 
      cART combinations and triglycerides (p = 0.001, p = 0.001, p = 0.050, p = 0.044, 
      p = 0.002, respectively). HOMA negatively correlated with levels of high density 
      lipoprotein (HDL) (Rho = -0.282; p = 0.025). PAI-1 (Rho = 0.334; p= 0.007) and 
      leptin (Rho = 0.492; p = 0.001) together with ferritin (Rho = 0.396, p = 0.001) 
      positively and significantly correlated with HOMA. Levels of IL-1 alpha, IL-1 beta, IFN 
      gamma, IL-2, IL-4, IL-6, IL-8, IL-10, adiponectin, MCP-1, resistin, TNF-alpha, CRP and 
      VEGF did not significantly correlate with HOMA. Further, multiple logistic 
      regression showed that there is a statistically significant correlation between 
      PAI, leptin and ferritin with HOMA levels (p = 0.042; p < 0.001, p = 0.009). 
      CONCLUSIONS: We showed significant correlation between PAI-1, leptin and 
      ferritin, independently of each other with HOMA, in HIV/AIDS patients on cART.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Dragovic, Gordana
AU  - Dragovic G
AD  - Department of Pharmacology, Clinical Pharmacology and Toxicology, School of 
      Medicine, University of Belgrade, Belgrade, Serbia. Electronic address: 
      gordana.dragovic@med.bg.ac.rs.
FAU - Sumarac-Dumanovic, Mirjana
AU  - Sumarac-Dumanovic M
AD  - Institute of Endocrinology, Diabetes and Diseases of Metabolism, University 
      Clinical Centre, Belgrade, Serbia.
FAU - Khawla, Al Musalhi
AU  - Khawla AM
AD  - Department of Clinical Biochemistry, Royal Free Hospital, University College 
      London, London, United Kingdom.
FAU - Soldatovic, Ivan
AU  - Soldatovic I
AD  - Institute for Biomedical Statistics, School of Medicine, University of Belgrade, 
      Belgrade, Serbia.
FAU - Andjic, Mladen
AU  - Andjic M
AD  - Department of Pharmacology, Clinical Pharmacology and Toxicology, School of 
      Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Jevtovic, Djordje
AU  - Jevtovic D
AD  - Infectious and Tropical Diseases Hospital, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Nair, Devaki
AU  - Nair D
AD  - Department of Clinical Biochemistry, Royal Free Hospital, University College 
      London, London, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180622
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*blood
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Ferritins/*blood
MH  - Homeostasis
MH  - Humans
MH  - Insulin/*blood
MH  - *Insulin Resistance
MH  - Leptin/*blood
MH  - Male
MH  - Plasminogen Activator Inhibitor 1/*blood
OTO - NOTNLM
OT  - Ferritin
OT  - HIV/AIDS patients
OT  - HOMA
OT  - Leptin
OT  - PAI-1
EDAT- 2018/06/26 06:00
MHDA- 2018/11/28 06:00
CRDT- 2018/06/26 06:00
PHST- 2018/04/09 00:00 [received]
PHST- 2018/06/09 00:00 [revised]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/06/26 06:00 [entrez]
AID - S0014-4800(18)30157-6 [pii]
AID - 10.1016/j.yexmp.2018.06.004 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2018 Aug;105(1):115-119. doi: 10.1016/j.yexmp.2018.06.004. Epub 
      2018 Jun 22.