PMID- 29940426
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20201209
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 96
DP  - 2018 Oct
TI  - Maternal high fat diet alters offspring epigenetic regulators, amygdala 
      glutamatergic profile and anxiety.
PG  - 132-141
LID - S0306-4530(18)30209-9 [pii]
LID - 10.1016/j.psyneuen.2018.06.015 [doi]
AB  - Maternal obesity during pregnancy can impact long-term health, predisposition to 
      disease, and risk of neurological disorders in offspring. This may arise from 
      disruption to epigenetic processes during offspring brain development. Using a 
      maternal high fat diet (mHFD) mouse model, we investigated the expression of 
      genes encoding epigenetic regulators in the brains of gestational day (GD) 17.5 
      mHFD offspring. We found significant, regionally unique changes in expression of 
      epigenetic regulators in the developing brain of mHFD offspring compared to 
      controls, with Gadd45b downregulated in medial prefrontal cortex, Mecp2 
      downregulated in amygdala, and sex-specific downregulation of Crebbp, Dnmt3b, and 
      Mecp2 in male mHFD hippocampus. Decreased Mecp2 in the amygdala was associated 
      with significant upregulation of the Mecp2-repressed gene, Tbr1, and an increased 
      number of TBR1(+) glutamatergic neurons in the basomedial nucleus of the 
      amygdala. Tbr1 upregulation in amygdala was also observed in postnatal day 8 (P8) 
      mHFD offspring, and levels of glutamate receptor gene Grin2b, and Fos, a marker 
      for neuronal activity, were increased. Indications of heightened excitatory drive 
      in mHFD offspring amygdala were associated with an anxiety-like phenotype, with 
      mHFD offspring displaying altered ultrasonic vocalization characteristics at P8, 
      and adult female mHFD offspring spending decreased time on the open arm of the 
      Elevated Plus Maze. Together, this data provides insight into sex-specific 
      offspring vulnerability to perinatal mHFD programming of anxiety-like behaviors.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Glendining, Kelly A
AU  - Glendining KA
AD  - Centre for Neuroendocrinology, Department of Anatomy, University of Otago School 
      of Biomedical Sciences, Dunedin, New Zealand.
FAU - Fisher, Lorryn C
AU  - Fisher LC
AD  - Centre for Neuroendocrinology, Department of Anatomy, University of Otago School 
      of Biomedical Sciences, Dunedin, New Zealand.
FAU - Jasoni, Christine L
AU  - Jasoni CL
AD  - Centre for Neuroendocrinology, Department of Anatomy, University of Otago School 
      of Biomedical Sciences, Dunedin, New Zealand. Electronic address: 
      christine.jasoni@otago.ac.nz.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180619
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Antigens, Differentiation)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Excitatory Amino Acid Agents)
RN  - 0 (Gadd45b protein, mouse)
RN  - 0 (Mecp2 protein, mouse)
RN  - 0 (Methyl-CpG-Binding Protein 2)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (Tbr1 protein, mouse)
SB  - IM
MH  - Amygdala/*metabolism
MH  - Animals
MH  - Antigens, Differentiation/genetics/metabolism
MH  - Anxiety/*metabolism
MH  - Anxiety Disorders
MH  - Brain
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Epigenesis, Genetic/*physiology
MH  - Excitatory Amino Acid Agents/metabolism
MH  - Female
MH  - Hippocampus
MH  - Male
MH  - Methyl-CpG-Binding Protein 2/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/metabolism
MH  - T-Box Domain Proteins
OTO - NOTNLM
OT  - Anxiety
OT  - Glutamate
OT  - Maternal high fat
OT  - Mecp2
OT  - Neurodevelopmental programming
OT  - Tbr1
EDAT- 2018/06/26 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/06/26 06:00
PHST- 2018/03/09 00:00 [received]
PHST- 2018/05/12 00:00 [revised]
PHST- 2018/06/18 00:00 [accepted]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/06/26 06:00 [entrez]
AID - S0306-4530(18)30209-9 [pii]
AID - 10.1016/j.psyneuen.2018.06.015 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2018 Oct;96:132-141. doi: 
      10.1016/j.psyneuen.2018.06.015. Epub 2018 Jun 19.