PMID- 29940544
OWN - NLM
STAT- MEDLINE
DCOM- 20190228
LR  - 20190228
IS  - 0025-7680 (Print)
IS  - 0025-7680 (Linking)
VI  - 78
IP  - 3
DP  - 2018
TI  - [Paracoccidioidomycosis: chronicle of a neglected disease].
PG  - 180-184
AB  - Paracoccidioidomycosis (PCM) is among the systemic mycoses which are endemic only 
      in Latin America. In Argentina, the vast majority of the cases are reported at 
      north of latitude 34.5 degrees  S. The disease is produced by thermodimorphic fungi of 
      the genus Paracoccidoides: P. brasiliensis (S1), P. americana (PS2), P. 
      restrepiensis (PS3), P. venezuelensis (PS4) y P. lutzii. The natural habitat of 
      members of this genus is the soil, where they produce infectious conidia. Little 
      is known, however, about their specific ecologic niche(s), and this knowledge gap 
      hampers the design of measures to control the infection. Rural male workers are 
      the group most at risk of developing PCM. Infection occurs by inhalation of 
      aerosolized conidia and may either be asymptomatic or cause mild respiratory 
      symptoms. In turn, this primary infection may be self-limited or progress to 
      severe pulmonary or disseminated disease. The disease has two clinical 
      presentations: (i) acute or subacute (juvenile), frequent in children, 
      adolescents and people with immunodeficiencies; and (ii) chronic progressive, in 
      adults. Active lesions often resolve into fibrotic scars which can cause 
      dysphagia, dysphonia, adrenal insufficiency, and intestinal obstruction. Although 
      efficient tools are available for diagnosis and treatment, the nonspecific nature 
      of PCM clinical manifestations frequently delay the diagnosis. In addition, the 
      poor adherence to long antifungal treatments allows the advance of the disease 
      and the development of extensive fibrosis compromising severely and permanently 
      respiratory and adrenal functions, thus altering the patient"s quality of life 
      and even causing his/her death.
FAU - Canteros, Cristina E
AU  - Canteros CE
AD  - Servicio Micosis Profundas, Departamento Micologia, INEI-ANLIS Dr. Carlos G. 
      Malbran, Buenos Aires, Argentina. E-mail ccanteros@anlis.gov.ar.
LA  - spa
PT  - Journal Article
TT  - Paracoccidioidomicosis: cronica de una enfermedad olvidada.
PL  - Argentina
TA  - Medicina (B Aires)
JT  - Medicina
JID - 0204271
SB  - IM
MH  - Humans
MH  - *Neglected Diseases
MH  - Paracoccidioides/*classification
MH  - *Paracoccidioidomycosis/diagnosis/parasitology/therapy
OTO - NOTNLM
OT  - Paracoccidioides spp.
OT  - invasive fungal infections
OT  - mycoses
OT  - neglected disease
EDAT- 2018/06/26 06:00
MHDA- 2019/03/01 06:00
CRDT- 2018/06/26 06:00
PHST- 2018/06/26 06:00 [entrez]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2019/03/01 06:00 [medline]
PST - ppublish
SO  - Medicina (B Aires). 2018;78(3):180-184.