PMID- 29940599
OWN - NLM
STAT- MEDLINE
DCOM- 20191008
LR  - 20191210
IS  - 1421-9697 (Electronic)
IS  - 0250-6807 (Linking)
VI  - 73
IP  - 1
DP  - 2018
TI  - Association of Nesfatin-1, Acylated Ghrelin and Cortisol with Scores of 
      Compulsion, Food Addiction, and Binge Eating in Adults with Normal Weight and 
      with Obesity.
PG  - 54-61
LID - 10.1159/000490357 [doi]
AB  - BACKGROUND/AIMS: The alterations of eating behavior are insufficiently recognized 
      in the clinical attention of adults with obesity. The objective of this study was 
      to examine the characteristics of overeating behavior and its association with 
      depression, perceived stress, acylated ghrelin, nestafin-1, and cortisol. 
      METHODS: This cross-sectional comparative study included 80 participants with 
      obesity and 50 with normal weight. The volunteers completed questionnaires to 
      evaluate symptoms of food addiction (FA), obsessive compulsive, binge eating 
      (BE), depression, and perceived stress. We measured glucose, lipids, acylated 
      ghrelin, nesfatin-1, and insulin in a fasting blood sample as well as urine 
      cortisol. We compared groups with students t test, and analysis of variance, and 
      tested associations by logistic and multiple regression. RESULTS: By multiple 
      regression, the BE total score was positively associated with the FA (p < 0.0001) 
      and depression total score (p < 0.0001). By logistic regression, the positive 
      score of FA was associated with ghrelin (p < 0.02). The perceived stress total 
      score was associated negatively with cortisol (p < 0.0006). CONCLUSION: The BE 
      and FA are strongly associated in agreement with the concept that both conditions 
      have overlapping features. Depressive symptoms are associated with symptoms of 
      disordered eating -behavior. FA positive score was associated with ghrelin. BE 
      total score was associated with nesfatin-1.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Lopez-Aguilar, Itzel
AU  - Lopez-Aguilar I
FAU - Ibarra-Reynoso, Lorena Del Rocio
AU  - Ibarra-Reynoso LDR
FAU - Malacara, Juan Manuel
AU  - Malacara JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180625
PL  - Switzerland
TA  - Ann Nutr Metab
JT  - Annals of nutrition & metabolism
JID - 8105511
RN  - 0 (Blood Glucose)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Ghrelin)
RN  - 0 (Lipids)
RN  - 0 (NUCB2 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nucleobindins)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Blood Glucose
MH  - Bulimia/*blood
MH  - Calcium-Binding Proteins/*blood
MH  - Case-Control Studies
MH  - Compulsive Behavior/blood
MH  - Cross-Sectional Studies
MH  - DNA-Binding Proteins/*blood
MH  - Depression/blood
MH  - Feeding Behavior
MH  - Female
MH  - Food Addiction/*blood
MH  - Ghrelin/*blood
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Lipids/blood
MH  - Male
MH  - Nerve Tissue Proteins/*blood
MH  - Nucleobindins
MH  - Obesity/*blood
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - Acylated ghrelin
OT  - Binge eating
OT  - Food addiction
OT  - Nesfatin-1
OT  - Obsessive compulsive disorder
EDAT- 2018/06/26 06:00
MHDA- 2019/10/09 06:00
CRDT- 2018/06/26 06:00
PHST- 2017/10/26 00:00 [received]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2019/10/09 06:00 [medline]
PHST- 2018/06/26 06:00 [entrez]
AID - 000490357 [pii]
AID - 10.1159/000490357 [doi]
PST - ppublish
SO  - Ann Nutr Metab. 2018;73(1):54-61. doi: 10.1159/000490357. Epub 2018 Jun 25.