PMID- 29940616
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20181024
IS  - 2066-8279 (Electronic)
IS  - 1220-0522 (Linking)
VI  - 59
IP  - 1
DP  - 2018
TI  - A morpho-functional study using PEP/LVET ratio and global longitudinal strain in 
      patients with dilated cardiomyopathy.
PG  - 93-103
AB  - AIM: To assess left ventricular (LV) systolic function and morphology in patients 
      with severe dilated cardiomyopathy (DCM), using both conventional and a complex 
      technique, speckle-tracking echocardiography, and evaluate the correlation 
      between pre-ejection period and left ventricular ejection period (PEP/LVET) 
      ratio, global longitudinal strain (GLS), and severity of the condition. PATIENTS, 
      MATERIALS AND METHODS: Seventeen patients were enrolled after rigorous criteria. 
      Echocardiography was performed in conventional and speckle-tracking mode, in all 
      patients with DCM, in sinus rhythm. LV dimensions, volumes and ejection fraction 
      (LVEF) were measured. PEP/LVET ratio was obtained from apical 5-chamber axis and 
      was defined as the time between QRS onset and LV ejection reported to LV ejection 
      period. Speckle-tracking imaging was performed in offline mode and GLS was 
      obtained from parasternal 4-, 3-, 2-chamber apical view, by averaging 
      longitudinal peak systolic strain of all 17 LV-segments. RESULTS: New York Heart 
      Association (NYHA) functional class correlated significantly with LVEF (-0.82; 
      p=0.0006), PEP/LVET (0.86; p=0.001) or GLS (0.85; p=0.0002). Considerable 
      correlations were between mitral regurgitation (MR) severity and LVEF (-0.65; 
      p=0.01) or PEP/LVET (0.69; p=0.0059), but higher were between MR severity and GLS 
      (0.76; p=0.0018). Tricuspid regurgitation (TR) grading correlated statistically 
      with LVEF (-0.62; p=0.01), PEP/LVET and GLS (0.6; p=0.018; and 0.62; p=0.014, 
      respectively). As opposed to the parameters in conventional echocardiography, GLS 
      correlated with DCM etiology (p=0.0046) and with the gender (p=0.048). 
      CONCLUSIONS: This study demonstrates that, in patients with DCM, assessment of 
      cardiac dyssynchrony can be accurately accomplished by combining parameters in 
      conventional and in speckle-tracking echocardiography.
FAU - Corici, Oana Maria
AU  - Corici OM
AD  - Department of Medical Informatics and Biostatistics, University of Medicine and 
      Pharmacy of Craiova, Romania; dragosado@yahoo.com.
FAU - Tanasie, Cornelia Andreea
AU  - Tanasie CA
FAU - Alexandru, Dragos Ovidiu
AU  - Alexandru DO
FAU - Florescu, Mihaela Corina
AU  - Florescu MC
FAU - Comanescu, Maria Victoria
AU  - Comanescu MV
FAU - Kamal, Kamal Constantin
AU  - Kamal KC
FAU - Tenea-Cojan, Tiberiu Stefanita
AU  - Tenea-Cojan TS
FAU - Iancau, Maria
AU  - Iancau M
FAU - Dinescu, Sorin Nicolae
AU  - Dinescu SN
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rom J Morphol Embryol
JT  - Romanian journal of morphology and embryology = Revue roumaine de morphologie et 
      embryologie
JID - 9112454
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Output/*physiology
MH  - Cardiomyopathy, Dilated/*diagnosis/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Ventricular Function, Left/*physiology
EDAT- 2018/06/26 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/06/26 06:00
PHST- 2018/06/26 06:00 [entrez]
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
AID - 590118093103 [pii]
PST - ppublish
SO  - Rom J Morphol Embryol. 2018;59(1):93-103.