PMID- 29940666
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20180806
IS  - 1439-3964 (Electronic)
IS  - 0172-4622 (Linking)
VI  - 39
IP  - 9
DP  - 2018 Sep
TI  - Immune and Inflammatory Response in Atopic Elite Endurance Athletes.
PG  - 720-725
LID - 10.1055/a-0633-9001 [doi]
AB  - The present study aimed to compare the immune and inflammatory responses between 
      atopic (n=20) and non-atopic (n=39) elite endurance athletes. Fifty-nine elite 
      runners and triathletes were assessed for the following measurements: Th(1), 
      Th(2) and lymphocyte phenotyping and plasma levels of cortisol, chemokines, 
      inflammatory cytokines and specific immunoglobulin E (IgE). Levels of salivary 
      IgA, allergic symptoms and training data were also evaluated. No difference was 
      observed in baseline lymphocyte levels. However, the Th(1) lymphocytes of atopic 
      athletes presented a lower response after activation. In contrast to this result, 
      levels of salivary IgA and CXCL9 chemokine were higher in the atopic athletes. It 
      was observed that the volume of training per week was linearly associated with 
      Th(1) levels, allergic symptoms and IgE levels. In addition, linear multiple 
      regression analysis demonstrated that the volume of training was the only factor 
      associated with allergic symptoms in atopic athletes (r=0.53; p=0.04). These 
      results suggest that compared to non-atopic athletes, atopic athletes present a 
      reduced Th(1) response and higher levels of salivary IgA. Training volume is 
      associated with the immune response and allergic symptoms, which suggests that 
      they may play a role in the atopy in elite endurance athletes.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Teixeira, Renata Nakata
AU  - Teixeira RN
AD  - Department of Physical Therapy, University of Sao Paulo, SP, Brazil.
FAU - Dos Santos Leite, Gerson
AU  - Dos Santos Leite G
AD  - Department of Physical Therapy, University of Sao Paulo, SP, Brazil.
FAU - Gorjao, Renata
AU  - Gorjao R
AD  - Institute of Physical Activity Sciences and Sports, Post-Graduation Program in 
      Human Movement Sciences, University Cruzeiro do Sul, Sao Paulo, Brazil.
FAU - Palmeira, Patricia
AU  - Palmeira P
AD  - School of Medicine, University of S.o Paulo, Sao Paulo, Brazil.
FAU - Santos, Cesar Miguel Momesso
AU  - Santos CMM
AD  - Institute of Physical Activity Sciences and Sports, Post-Graduation Program in 
      Human Movement Sciences, University Cruzeiro do Sul, Sao Paulo, Brazil.
FAU - Zambonatto, Raquel
AU  - Zambonatto R
AD  - Institute of Physical Activity Sciences and Sports, Post-Graduation Program in 
      Human Movement Sciences, University Cruzeiro do Sul, Sao Paulo, Brazil.
FAU - de Oliveira, Heloisa Helena
AU  - de Oliveira HH
AD  - Institute of Physical Activity Sciences and Sports, Post-Graduation Program in 
      Human Movement Sciences, University Cruzeiro do Sul, Sao Paulo, Brazil.
FAU - Levada, Adriana Cristina
AU  - Levada AC
AD  - Institute of Physical Activity Sciences and Sports, Post-Graduation Program in 
      Human Movement Sciences, University Cruzeiro do Sul, Sao Paulo, Brazil.
FAU - Fiks, Iara Nely
AU  - Fiks IN
AD  - Pulmonary Division, Heart Institute (InCor), University of S.o Paulo, Sao Paulo, 
      Brazil.
FAU - Carvalho, Celso Ricardo Fernandes
AU  - Carvalho CRF
AD  - Department of Physical Therapy, University of Sao Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180625
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin A)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Cross-Sectional Studies
MH  - Cytokines/*blood
MH  - Humans
MH  - Hydrocortisone/metabolism
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin A/metabolism
MH  - Immunoglobulin E/blood
MH  - Inflammation/*immunology
MH  - Male
MH  - Physical Conditioning, Human
MH  - Physical Endurance/*physiology
MH  - Saliva/metabolism
MH  - Sports/*physiology
MH  - *Th1-Th2 Balance
MH  - Young Adult
COIS- The authors declare no conflict of interest.
EDAT- 2018/06/26 06:00
MHDA- 2018/08/07 06:00
CRDT- 2018/06/26 06:00
PHST- 2018/06/26 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
PHST- 2018/06/26 06:00 [entrez]
AID - 10.1055/a-0633-9001 [doi]
PST - ppublish
SO  - Int J Sports Med. 2018 Sep;39(9):720-725. doi: 10.1055/a-0633-9001. Epub 2018 Jun 
      25.