PMID- 29941995
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20191022
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jun 25
TI  - Social dominance predicts hippocampal glucocorticoid receptor recruitment and 
      resilience to prenatal adversity.
PG  - 9595
LID - 10.1038/s41598-018-27988-9 [doi]
LID - 9595
AB  - The developing fetus is highly sensitive to prenatal stress, which may alter 
      Hypothalamic-Pituitary-Adrenal (HPA) axis programming and increase the risk of 
      behavioral disorders. There is high variability among the human population, 
      wherein many offspring of stressed pregnancies display resilience to adversity, 
      while the remainder displays vulnerability. In order to identify biological 
      substrates mediating between resilience or vulnerability to prenatal adversity, 
      we exposed stress-resistant Dominant (Dom) and stress-sensitive Submissive (Sub) 
      mice to mild prenatal restraint stress (PRS, 45 min on gestational days (GD) 15, 
      16 and 17). We hypothesized that PRS would differentially alter prenatal 
      programming of limbic regions regulating the HPA axis and affect among Dom and 
      Sub offspring. Indeed, PRS increased Sub offspring's serum corticosterone, and 
      exaggerated their anxiety- and depressive-like behavior, while Dom offspring 
      remained resilient to the hormonal and behavioral consequences of PRS. Moreover, 
      PRS exposure markedly facilitated glucocorticoid receptor (GR) recruitment to the 
      hippocampus among Dom mice in response to restraint stress, which may be 
      responsible for their resilience to stressful challenge. These findings suggest 
      proclivity to adaptive or maladaptive prenatal programming of hippocampal GR 
      recruitment to be inheritable and predictable by social dominance or 
      submissiveness.
FAU - Gross, Moshe
AU  - Gross M
AD  - Department of Molecular Biology, Ariel University, Ariel, 4070000, Israel.
FAU - Romi, Hava
AU  - Romi H
AD  - Department of Molecular Biology, Ariel University, Ariel, 4070000, Israel.
FAU - Miller, Ayala
AU  - Miller A
AD  - Department of Molecular Biology, Ariel University, Ariel, 4070000, Israel.
FAU - Pinhasov, Albert
AU  - Pinhasov A
AD  - Department of Molecular Biology, Ariel University, Ariel, 4070000, Israel. 
      albertpi@ariel.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180625
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Receptors, Glucocorticoid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Anxiety/psychology
MH  - Behavior, Animal
MH  - Corticosterone/blood
MH  - Depression/psychology
MH  - Hippocampus/*metabolism
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - *Interpersonal Relations
MH  - Male
MH  - Mice
MH  - Protein Transport
MH  - Receptors, Glucocorticoid/*metabolism
MH  - *Resilience, Psychological
MH  - Stress, Psychological/blood/*metabolism/*psychology
PMC - PMC6018627
COIS- The authors declare no competing interests.
EDAT- 2018/06/27 06:00
MHDA- 2019/10/23 06:00
PMCR- 2018/06/25
CRDT- 2018/06/27 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/06/12 00:00 [accepted]
PHST- 2018/06/27 06:00 [entrez]
PHST- 2018/06/27 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/06/25 00:00 [pmc-release]
AID - 10.1038/s41598-018-27988-9 [pii]
AID - 27988 [pii]
AID - 10.1038/s41598-018-27988-9 [doi]
PST - epublish
SO  - Sci Rep. 2018 Jun 25;8(1):9595. doi: 10.1038/s41598-018-27988-9.