PMID- 29942980 OWN - NLM STAT- MEDLINE DCOM- 20200421 LR - 20200421 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 269 IP - 8 DP - 2019 Dec TI - Relationship between duration of untreated prodromal symptoms and symptomatic and functional recovery. PG - 871-877 LID - 10.1007/s00406-018-0917-z [doi] AB - Our previous study has found that a long duration of untreated prodromal symptoms (DUPrS) does not increase the conversion risk to psychosis in individuals with attenuated psychosis syndrome (APS). However, whether a long DUPrS will lead to other poor outcomes remains unknown. The purpose of this study was to analyse the association between the DUPrS and outcomes (symptomatic and functional recovery) in APS population. A post hoc analysis was performed in 391 individuals with APS as identified by the structured interview. APS subjects had follow-up interviews every 6 months for 2 years following diagnosis. Poor functional outcome was defined as a Global Assessment of Functioning (GAF) score less than 60 at the time of follow-up. Poor symptomatic outcome was defined as at least one of the positive symptoms rated scores of 3 or higher. A post hoc analysis was performed in 391 individuals with APS as identified by the structured interview. APS subjects had follow-up interviews every 6 months for 2 years following diagnosis. Poor functional outcome was defined as a Global Assessment of Functioning (GAF) score less than 60 at the time of follow-up. Poor symptomatic outcome was defined as at least one of the positive symptoms rated scores of 3 or higher. Of total 391 individuals, 334 were followed up for 2 years to assess clinical outcome, 82 (24.6%) had shown conversion to psychosis, 79 (23.7%) met the criteria of poor functioning outcome, and 145 (43.4%) met the criteria of poor symptomatic outcome. A significant correlation between GAF scores and DUPrS was observed in the non-converter group, but not in the converters. Individuals with APS who had a longer DUPrS were correlated with poorer functional outcome. However, it was not correlated with poorer symptomatic outcome. While a longer DUPrS was not related to poor symptomatic outcome, it was significantly related to poor functional outcome. Our findings highlight the importance of reducing DUPrS to decrease future functional impairment in populations at risk for psychosis. FAU - Zhang, TianHong AU - Zhang T AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. zhang_tianhong@126.com. FAU - Xu, LiHua AU - Xu L AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Cui, HuiRu AU - Cui H AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Tang, XiaoChen AU - Tang X AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Wei, YanYan AU - Wei Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Wang, Yan AU - Wang Y AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Hu, Qiang AU - Hu Q AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Qian, ZhenYing AU - Qian Z AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Liu, XiaoHua AU - Liu X AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. FAU - Li, ChunBo AU - Li C AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. AD - CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Beijing, People's Republic of China. FAU - Wang, JiJun AU - Wang J AD - Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Psychotic Disorders, 600 Wanping Nan Road, Shanghai, 200030, People's Republic of China. jijunwang27@163.com. AD - CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Beijing, People's Republic of China. jijunwang27@163.com. AD - Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai, People's Republic of China. jijunwang27@163.com. LA - eng GR - 2016YFC1306803/Ministry of Science and Technology of the People's Republic of China/ GR - 81671329, 81671332/National Natural Science Foundation of China/ GR - 13dz2260500/Shanghai Key Laboratory of Psychotic Disorders/ GR - 16CR2015A, 16CR3016A/Clinical Research Plan of SHDC/ GR - 2016-FX-01/Shanghai Mental Health Center Foundation/ GR - 16XD1402400/Program of Shanghai Academic Research Leader/ PT - Journal Article DEP - 20180625 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM MH - Female MH - Humans MH - Interview, Psychological MH - Male MH - *Prodromal Symptoms MH - Psychotic Disorders/diagnosis/psychology/*therapy MH - Remission Induction MH - Time Factors MH - Young Adult OTO - NOTNLM OT - Clinical high risk OT - Duration of untreated prodromal symptoms OT - Duration of untreated psychosis OT - Outcome OT - Prodromal psychosis EDAT- 2018/06/27 06:00 MHDA- 2020/04/22 06:00 CRDT- 2018/06/27 06:00 PHST- 2018/03/13 00:00 [received] PHST- 2018/06/18 00:00 [accepted] PHST- 2018/06/27 06:00 [pubmed] PHST- 2020/04/22 06:00 [medline] PHST- 2018/06/27 06:00 [entrez] AID - 10.1007/s00406-018-0917-z [pii] AID - 10.1007/s00406-018-0917-z [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2019 Dec;269(8):871-877. doi: 10.1007/s00406-018-0917-z. Epub 2018 Jun 25.