PMID- 29944703
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20240327
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 6
DP  - 2018
TI  - Association of serum BDNF levels and the BDNF Val66Met polymorphism with the 
      sleep pattern in healthy young adults.
PG  - e0199765
LID - 10.1371/journal.pone.0199765 [doi]
LID - e0199765
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is widely expressed in the 
      brain and plays an important role in neuronal maintenance, plasticity, and 
      neurogenesis. Prior studies have found that decreased serum BDNF levels are 
      associated with perceived stress, depression, or sleep disturbances in humans. 
      STUDY OBJECTIVES: To elucidate whether the serum BDNF levels and BDNF genotype 
      were associated with the sleep pattern in healthy young adults. METHODS: The 
      study group consisted of 79 healthy paid volunteers (45 men, 34 women) aged 20 to 
      29 years. Serum BDNF levels were measured with an enzyme-linked immunosorbent 
      assay, and a single-nucleotide polymorphism (Val66Met) in the BDNF gene was 
      assessed with a TaqMan assay. Details of the sleep pattern were obtained from 
      1-week sleep/wake records. RESULTS: Serum BDNF levels were significantly 
      associated with sleep parameters on weekends, whereas no such association was 
      found on weekdays. On weekends, longer total sleep time and time in bed, and 
      later mid-sleep time were associated with lower serum BDNF levels. The difference 
      between mid-sleep time on weekdays and that on weekends, otherwise known as 
      social jetlag, was negatively associated with serum BDNF levels. Met/Met 
      homozygotes of the BDNF Val66Met polymorphism had significantly longer time in 
      bed on weekends than Val/Val homozygotes. Heterozygotes did not differ from 
      Val/Val homozygotes. CONCLUSIONS: We first found that serum BDNF levels and the 
      BDNF Val66Met polymorphism in healthy young adults were associated with the sleep 
      pattern on weekends but not with that on weekdays, suggesting that the systems 
      involved in BDNF control may be linked to endogenous sleep characteristics rather 
      than the socially constrained sleep schedule in healthy young adults.
FAU - Saitoh, Kaori
AU  - Saitoh K
AD  - Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Furihata, Ryuji
AU  - Furihata R
AD  - Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Kaneko, Yoshiyuki
AU  - Kaneko Y
AD  - Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Suzuki, Masahiro
AU  - Suzuki M
AUID- ORCID: 0000-0002-3873-8727
AD  - Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Takahashi, Sakae
AU  - Takahashi S
AD  - Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
FAU - Uchiyama, Makoto
AU  - Uchiyama M
AD  - Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180626
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
EIN - PLoS One. 2018 Aug 2;13(8):e0201994. PMID: 30071105
MH  - Adult
MH  - Amino Acid Substitution
MH  - *Brain-Derived Neurotrophic Factor/blood/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Sleep/*physiology
PMC - PMC6019675
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/06/27 06:00
MHDA- 2018/12/18 06:00
PMCR- 2018/06/26
CRDT- 2018/06/27 06:00
PHST- 2018/04/10 00:00 [received]
PHST- 2018/06/13 00:00 [accepted]
PHST- 2018/06/27 06:00 [entrez]
PHST- 2018/06/27 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/06/26 00:00 [pmc-release]
AID - PONE-D-18-10721 [pii]
AID - 10.1371/journal.pone.0199765 [doi]
PST - epublish
SO  - PLoS One. 2018 Jun 26;13(6):e0199765. doi: 10.1371/journal.pone.0199765. 
      eCollection 2018.