PMID- 29944778
OWN - NLM
STAT- MEDLINE
DCOM- 20191016
LR  - 20191016
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 30
IP  - 9
DP  - 2018 Sep
TI  - Modulation of synaptic inputs in magnocellular neurones in a rat model of cancer 
      cachexia.
PG  - e12630
LID - 10.1111/jne.12630 [doi]
AB  - In cancer cachexia, abnormal metabolism and neuroendocrine dysfunction cause 
      anorexia, tissue damage and atrophy, which can in turn alter body fluid balance. 
      Arginine vasopressin, which regulates fluid homeostasis, is secreted by 
      magnocellular neurosecretory cells (MNCs) of the hypothalamic supraoptic nucleus. 
      Arginine vasopressin secretion by MNCs is regulated by both excitatory and 
      inhibitory synaptic activity, alterations in plasma osmolarity and various 
      peptides, including angiotensin II. In the present study, we used whole-cell 
      patch-clamp recordings of brain slices to determine whether hyperosmotic 
      stimulation and/or angiotensin II potentiate excitatory synaptic input in a rat 
      model of cancer cachexia, similar to their effects in normal (control) rats. 
      Hyperosmotic (15 and 60 mmol L(-1)   mannitol) stimulation and angiotensin II 
      (0.1 mumol L(-1) ) increased the frequency, but not the amplitude, of miniature 
      excitatory postsynaptic currents in normal rats; in model rats, both effects were 
      significantly attenuated. These results suggest that cancer cachexia alters 
      supraoptic MNC sensitivity to osmotic and angiotensin II stimulation.
CI  - (c) 2018 British Society for Neuroendocrinology.
FAU - Yokoyama, Toru
AU  - Yokoyama T
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
AD  - Department of Physiology, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
AD  - Department of Anesthesiology and Critical Care Medicine, Jichi Medical 
      University, Shimotsuke, Japan.
FAU - Terawaki, Kiyoshi
AU  - Terawaki K
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
AD  - Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan.
FAU - Minami, Kouichiro
AU  - Minami K
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
AD  - Department of Physiology, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
AD  - Department of Anesthesiology and Critical Care Medicine, Jichi Medical 
      University, Shimotsuke, Japan.
FAU - Miyano, Kanako
AU  - Miyano K
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
FAU - Nonaka, Miki
AU  - Nonaka M
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
FAU - Uzu, Miaki
AU  - Uzu M
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
FAU - Kashiwase, Yohei
AU  - Kashiwase Y
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
AD  - Laboratory of Molecular Pathology and Metabolic Disease, Faculty of 
      Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan.
FAU - Yanagihara, Kazuyoshi
AU  - Yanagihara K
AD  - Division of Biomarker Discovery, Exploratory Oncology Research & Clinical Trial 
      Center, National Cancer Center, Kashiwa, Japan.
FAU - Ueta, Yoichi
AU  - Ueta Y
AUID- ORCID: 0000-0003-0702-9538
AD  - Department of Physiology, School of Medicine, University of Occupational and 
      Environmental Health, Kitakyushu, Japan.
FAU - Uezono, Yasuhito
AU  - Uezono Y
AD  - Cancer Pathophysiology Division, National Cancer Center Research Institute, 
      Tokyo, Japan.
LA  - eng
GR  - Ministry of Health, Labour and Welfare/International
GR  - 15lk0310003h0001/Research Project for Improving Quality in Healthcare and 
      Collecting Scientific Evidence on Integrative Medicine/International
GR  - 16lk0310020h0001/Research Project for Improving Quality in Healthcare and 
      Collecting Scientific Evidence on Integrative Medicine/International
GR  - Japan Agency for Medical Research and Development/International
GR  - 15K08215/Ministry of Education, Culture, Sports, Science and Technology of 
      Japan/International
GR  - Foundation for Promotion of Cancer Research in Japan/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 11128-99-7 (Angiotensin II)
RN  - 3OWL53L36A (Mannitol)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Cachexia/etiology/*physiopathology
MH  - Cell Line, Tumor
MH  - Disease Models, Animal
MH  - Excitatory Postsynaptic Potentials/drug effects/*physiology
MH  - Male
MH  - Mannitol/pharmacology
MH  - Miniature Postsynaptic Potentials/drug effects/*physiology
MH  - Neoplasm Transplantation
MH  - Neoplasms/complications/*physiopathology
MH  - Neurons/drug effects/*physiology
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Supraoptic Nucleus/drug effects/*physiopathology
OTO - NOTNLM
OT  - cachexia
OT  - miniature excitatory potentials
OT  - patch-clamp techniques
OT  - supraoptic nucleus
OT  - whole-cell recordings
EDAT- 2018/06/27 06:00
MHDA- 2019/10/17 06:00
CRDT- 2018/06/27 06:00
PHST- 2017/04/19 00:00 [received]
PHST- 2018/06/24 00:00 [accepted]
PHST- 2018/06/27 06:00 [pubmed]
PHST- 2019/10/17 06:00 [medline]
PHST- 2018/06/27 06:00 [entrez]
AID - 10.1111/jne.12630 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2018 Sep;30(9):e12630. doi: 10.1111/jne.12630.